World Library  

Other People Who Read Plos One : Role and Regulation of the Flp, Volume 8 Also Read


 
  • Cover Image

Plos One : Morphology and Viscoelasticity of Actin Networks Formed...

By: Laurent Kreplak

Description : Actin filaments and associated actin binding proteins play an essential role in governing the mechanical properties of eukaryotic cells. Even though cells have multiple actin binding proteins (ABPs) that exist simultaneously to maintain the structural and mechanical integrity of the cellular cytoskeleton, how these proteins work together to determine the properties of actin networks is not clearly understood. The ABP, palladin, is essential for the maintena...

Read More
  • Cover Image

Plos One : the Unique Structure of the Apicoplast Genome of the Ro...

By: Georges Snounou

Description : The apicoplast, a non-photosynthetic plastid of apicomplexan species, has an extremely reduced but highly conserved genome. Here, the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi (Pcc) isolate CB was characterized. Although the set of genes in the genome is identical, the copy number of some tRNA genes differs between Pcc and other Plasmodium species because the Pcc DNA has only one rRNA/tRNA gene cluster, which is normally ...

Read More
  • Cover Image

Plos One : a Systemically-administered Small Molecule Antagonist o...

By: Mehrdad Matloubian

Description : A goal for developers of immunomodulatory drugs has long been a systemically administered small molecule that can selectively inhibit inflammation in specific tissues. The chemokine receptor CCR9 is an attractive target for this approach, as entry of T cells into the small intestine from blood requires interaction between CCR9 and its ligand CCL25. We have tested the ability of a small molecule CCR9 antagonist, CCX8037, to inhibit antigen-mediated T cell ac...

Read More
  • Cover Image

Plos One : Induction of Labor and Risk of Postpartum Hemorrhage in...

By: Shannon M. Hawkins

Description : Even in low risk women, induction of labor, regardless of the method used, is associated with a higher risk of PPH than spontaneous labor. However, there was no excess risk of PPH in women who underwent induction of labor for non-standard indications. This raises the hypothesis that the higher risk of PPH associated with labor induction may be limited to unfavorable obstetrical situations.

Read More
  • Cover Image

Plos One : a Key Role for Nectin-1 in the Ventral Hippocampus in C...

By: Georges Chapouthier

Description : Nectins are cell adhesion molecules that are widely expressed in the brain. Nectin expression shows a dynamic spatiotemporal regulation, playing a role in neural migratory processes during development. Nectin-1 and nectin-3 and their heterophilic trans-interactions are important for the proper formation of synapses. In the hippocampus, nectin-1 and nectin-3 localize at puncta adherentia junctions and may play a role in synaptic plasticity, a mechanism essen...

Read More
  • Cover Image

Plos One : in Captive Rhesus MacAques, Cervicovaginal Inflammation...

By: Aftab A. Ansari

Description : Vaginal inoculation of rhesus macaques (RM) with simian immunodeficiency virus (SIV) has been used to study the biology of HIV transmission. Although the results of vaginal SIV transmission experiments could be affected by vaginal inflammation, studies to date have been conducted without regard to levels of pre-existing genital inflammation present in RM. We collected cevicovaginal secretions (CVS) from 33–36 RM during the mid menstrual cycle (day 10–20) at...

Read More
  • Cover Image

Plos One : Cognitive Dysfunction Precedes the Onset of Motor Sympt...

By: Xiaoxi Zhuang

Description : Parkinson’s disease (PD) is a neurodegenerative disorder primarily characterized by progressive loss of dopamine neurons, leading to loss of motor coordination. However, PD is associated with a high rate of non-motor neuropsychiatric comorbities that often develop before the onset of movement symptoms. The MitoPark transgenic mouse model is the first to recapitulate the cardinal clinical features, namely progressive neurodegeneration and death of neurons, l...

Read More
  • Cover Image

Plos One : Mir-421 and Mir-30C Inhibit Serpine 1 Gene Expression i...

By: Brian P. Chadwick

Description : In this work, we assessed whether SERPINE1 expression could be under the influence of microRNAs (miRNAs) predicted to bind the SERPINE1 39UTR region. We specifically focused on the 39UTR region harboring a common polymorphism, rs1050955, that have been found associated to SERPINE1 monocyte expression, and investigated whether the presence of different alleles at rs1050955 could modify the miRNAs binding efficiency and affect PAI-1 protein levels. We demonst...

Read More
  • Cover Image

Plos One : Modeling the Habitat Retreat of the Rediscovered Endemi...

By: Nicolas Salamin

Description : Survey data over the last 100 years indicate that populations of the endemic Hawaiian leafroller moth, Omiodes continuatalis (Wallengren) (Lepidoptera : Crambidae), have declined, and the species is extirpated from large portions of its original range. Declines have been attributed largely to the invasion of non-native parasitoid species into Hawaiian ecosystems. To quantify changes in O. continuatalis distribution, we applied the maximum entropy modeling a...

Read More
  • Cover Image

Plos One : Lymphatic and Angiogenic Candidate Genes Predict the De...

By: Robert Lafrenie

Description : The purposes of this study were to evaluate for differences in phenotypic and genotypic characteristics in women who did and did not develop lymphedema (LE) following breast cancer treatment. Breast cancer patients completed a number of self-report questionnaires. LE was evaluated using bioimpedance spectroscopy. Genotyping was done using a custom genotyping array. No differences were found between patients with (n = 155) and without LE (n = 387) for the ma...

Read More
  • Cover Image

Plos One : Cyclooxygenase-1 and Prostacyclin Production by Endothe...

By: Christianne Bandeira De Melo

Description : This study aimed at evaluating the relative contribution of endothelial cyclooxygenase-1 and -2 (COX-1 and COX-2) to prostacyclin (PGI2) production in the presence of mild oxidative stress resulting from autooxidation of polyphenols such as (-)-epigallocatechin 3-gallate (EGCG), using both endothelial cells in culture and isolated blood vessels. EGCG treatment resulted in an increase in hydrogen peroxide formation in human umbilical vein endothelial cells. ...

Read More
  • Cover Image

Plos One : on the Relevance of Sophisticated Structural Annotation...

By: Narcis Fernandez-fuentes

Description : Disulfide bridges strongly constrain the native structure of many proteins and predicting their formation is therefore a key sub-problem of protein structure and function inference. Most recently proposed approaches for this prediction problem adopt the following pipeline : first they enrich the primary sequence with structural annotations, second they apply a binary classifier to each candidate pair of cysteines to predict disulfide bonding probabilities a...

Read More
  • Cover Image

Plos One : Coregulation of Terpenoid Pathway Genes and Prediction ...

By: Michael Otto

Description : The isoprenoid pathway converts pyruvate to isoprene and related isoprenoid compounds in plants and some bacteria. Currently, this pathway is of great interest because of the critical role that isoprenoids play in basic cellular processes, as well as the industrial value of metabolites such as isoprene. Although the regulation of several pathway genes has been described, there is a paucity of information regarding system level regulation and control of the ...

Read More
  • Cover Image

Plos One : Comparison and Analysis of Zinc and Cobalt-based System...

By: Dennis Salahub

Description : In nature, the zinc metalloenzyme carbonic anhydrase II (CAII) efficiently catalyzes the conversion of carbon dioxide (CO2) to bicarbonate under physiological conditions. Many research efforts have been directed towards the development of small molecule mimetics that can facilitate this process and thus have a beneficial environmental impact, but these efforts have met very limited success. Herein, we undertook quantum mechanical calculations of four mimeti...

Read More
  • Cover Image

Plos One : Nucleolin Participates in Dna Double-strand Break- Indu...

By: Thomas G. Hofmann

Description : H2AX is an important factor for chromatin remodeling to facilitate accumulation of DNA damage-related proteins at DNA double-strand break (DSB) sites. In order to further understand the role of H2AX in the DNA damage response (DDR), we attempted to identify H2AX-interacting proteins by proteomics analysis. As a result, we identified nucleolin as one of candidates. Here, we show a novel role of a major nucleolar protein, nucleolin, in DDR. Nucleolin interact...

Read More
  • Cover Image

Plos One : Functional Status and All-cause Mortality in Serious Me...

By: Antony Bayer

Description : Functional impairment in people with serious mental illness diagnoses is a marker of increased mortality risk, possibly in younger age groups as a marker of negative symptomatology.

Read More
  • Cover Image

Plos One : Critical Roles of P53 in Epithelial-mesenchymal Transit...

By: Wing-kin Syn

Description : Hepatocellular carcinoma (HCC) is one of the most malignant tumors and the biggest obstacle in curing HCC is its high metastasis potential. Alteration of p53 is the most frequent genetic change found in HCC. Although the biological function of p53 in tumor initiation and progression has been well characterized, whether or not p53 is implicated in metastasis of HCC is largely unknown. In this study, we analyzed the potential functions of p53 in epithelial-me...

Read More
  • Cover Image

Plos One : Adaptive Evolution of Escherichia Coli to an Α-peptide,...

By: Mark Alexander Webber

Description : Antimicrobial peptides (AMPs) and synthetic analogues thereof target conserved structures of bacterial cell envelopes and hence, development of resistance has been considered an unlikely event. However, recently bacterial resistance to AMPs has been observed, and the aim of the present study was to determine whether bacterial resistance may also evolve against synthetic AMP analogues, e.g. a-peptide/b-peptoid peptidomimetics. E. coli ATCC 25922 was exposed ...

Read More
  • Cover Image

Plos One : Lack of Effect of the Salmonella Deubiquitinase Ssel on...

By: Jean-pierre Gorvel

Description : Intracellular replication of Salmonella enterica requires effector proteins translocated across the Salmonella-containing vacuolar membrane by Salmonella pathogenicity island-2 (SPI-2) encoded type III secretion system (T3SS). The SPI-2 T3SS effector SseL is a deubiquitinase that contributes to virulence in mice. Previous work has produced conflicting evidence as to the involvement of SseL in interference with the NF-kB pathway. To attempt to clarify these ...

Read More
  • Cover Image

Plos One : Chemical Communication Between the Endophytic Fungus Pa...

By: Vishnu Chaturvedi

Description : Paraconiothyrium variabile, one of the specific endophytic fungi isolated from the host plant Cephalotaxus harringtonia, possesses the faculty to inhibit the growth of common phytopathogens, thus suggesting a role in its host protection. A strong antagonism between the endophyte P. variabile and Fusarium oxysporum was observed and studied using optic and electronic microscopies. A disorganization of the mycelium of F. oxysporum was thus noticed. Interesting...

Read More
 
1
|
2
|
3
Records: 1 - 20 of 45 - Pages: 



Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.