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3-methyl-2-oxobutanoate Hydroxymethyltransferase

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Title: 3-methyl-2-oxobutanoate Hydroxymethyltransferase  
Author: World Heritage Encyclopedia
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Subject: List of EC numbers (EC 2)
Publisher: World Heritage Encyclopedia

3-methyl-2-oxobutanoate Hydroxymethyltransferase

3-methyl-2-oxobutanoate hydroxymethyltransferase
EC number CAS number IntEnz BRENDA ExPASy KEGG MetaCyc metabolic pathway
PRIAM PDB structures PDBsum
Gene Ontology EGO

In chemical reaction

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O \rightleftharpoons tetrahydrofolate + 2-dehydropantoate

The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, 3-methyl-2-oxobutanoate, and H2O, whereas its two products are tetrahydrofolate and 2-dehydropantoate.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase. Other names in common use include alpha-ketoisovalerate hydroxymethyltransferase, dehydropantoate hydroxymethyltransferase, ketopantoate hydroxymethyltransferase, oxopantoate hydroxymethyltransferase, 5,10-methylene tetrahydrofolate:alpha-ketoisovalerate, and hydroxymethyltransferase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies

As of late 2007, 4 1OY0.


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