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Title: Ctdp1  
Author: World Heritage Encyclopedia
Language: English
Subject: Phosphoprotein phosphatase
Publisher: World Heritage Encyclopedia


CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
PDB rendering based on 1onv.
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.[1][2][3]

This gene encodes a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA polymerase II holoenzyme complex. Alternative splicing of this gene results in two transcript variants encoding 2 different isoforms.[3]


CTDP1 has been shown to interact with WD repeat-containing protein 77,[4] GTF2F1[2] and POLR2A.[5]


Further reading

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