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Cyclin-dependent kinase 8

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Title: Cyclin-dependent kinase 8  
Author: World Heritage Encyclopedia
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Subject: Postreplication checkpoint, Cellular apoptosis susceptibility protein, Cyclin B2, CDKN2D, Start point (yeast)
Publisher: World Heritage Encyclopedia

Cyclin-dependent kinase 8

Cyclin-dependent kinase 8
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; K35
External IDs ChEMBL: GeneCards:
EC number
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene.[1][2] The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.[2] See also Protein kinase domain to view the more general properties of kinases.


Cyclin-dependent kinase 8 has been shown to interact with MED16,[3][4] MED26,[5] MED17,[3][4] MED14,[3][6] CREB binding protein,[7] MED1,[3][4] MED6,[3][4][6][8] MED24,[3][4] CCNC,[1][4][6][7][9] POLR2A,[7] MED21,[3][4][7][10] SMARCB1,[7] MED12[3][4] and CRSP3.[4][6]


  1. ^ a b Tassan JP, Jaquenoud M, Leopold P, Schultz SJ, Nigg EA (Oct 1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc Natl Acad Sci U S A 92 (19): 8871–5.  
  2. ^ a b "Entrez Gene: CDK8 cyclin-dependent kinase 8". 
  3. ^ a b c d e f g h Ito, M; Yuan C X; Malik S; Gu W; Fondell J D; Yamamura S; Fu Z Y; Zhang X; Qin J; Roeder R G (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell (UNITED STATES) 3 (3): 361–70.  
  4. ^ a b c d e f g h i Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro".  
  5. ^ Sato, Shigeo; Tomomori-Sato Chieri, Parmely Tari J, Florens Laurence, Zybailov Boris, Swanson Selene K, Banks Charles A S, Jin Jingji, Cai Yong, Washburn Michael P, Conaway Joan Weliky, Conaway Ronald C (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell (United States) 14 (5): 685–91.  
  6. ^ a b c d Wang, G; Cantin G T; Stevens J L; Berk A J (Jul 2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract". Mol. Cell. Biol. (United States) 21 (14): 4604–13.  
  7. ^ a b c d e Cho, H; Orphanides G; Sun X; Yang X J; Ogryzko V; Lees E; Nakatani Y; Reinberg D (Sep 1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. (UNITED STATES) 18 (9): 5355–63.  
  8. ^ Yang, Fajun; DeBeaumont Rosalie; Zhou Sharleen; Näär Anders M (Feb 2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator".  
  9. ^ Zhang, Y; Iratni R; Erdjument-Bromage H; Tempst P; Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell (UNITED STATES) 89 (3): 357–64.  
  10. ^ Suñé, C; Hayashi T; Liu Y; Lane W S; Young R A; Garcia-Blanco M A (Oct 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. (UNITED STATES) 17 (10): 6029–39.  

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