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Title: Dcp2  
Author: World Heritage Encyclopedia
Language: English
Subject: Polyuridylation, DCP1B, Cleavage factor, EDC3, PRPF4B
Publisher: World Heritage Encyclopedia


Decapping mRNA 2
Symbols  ; NUDT20
External IDs GeneCards:
EC number
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.[1][2][3] DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM][3]


DCP2 has been shown to interact with DCP1A[4] and UPF1.[2][5]


  1. ^ Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (Oct 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme pro-caratine". Proc Natl Acad Sci U S A 99 (20): 12663–8.  
  2. ^ a b Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol 22 (23): 8114–21.  
  3. ^ a b "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)". 
  4. ^ Lykke-Andersen, Jens (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell. Biol. (United States) 22 (23): 8114–21.  
  5. ^ Lejeune, Fabrice; Li Xiaojie; Maquat Lynne E (Sep 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell (United States) 12 (3): 675–87.  

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