World Library  
Flag as Inappropriate
Email this Article

Nuclear receptor coactivator 3

Article Id: WHEBN0011932347
Reproduction Date:

Title: Nuclear receptor coactivator 3  
Author: World Heritage Encyclopedia
Language: English
Subject: Histone acetyltransferase, AIB, Androgen receptor, Glucocorticoid receptor, Estrogen receptor alpha, IKBKG, CREB-binding protein, IKK2, Breast cancer classification
Publisher: World Heritage Encyclopedia

Nuclear receptor coactivator 3

Nuclear receptor coactivator 3
PDB rendering based on 1kbh.
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene.[1][2] NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).


NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression.[3][4]

Clinical significance

The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment.[5][6]


Nuclear receptor coactivator 3 has been shown to interact with DDX17,[7] IKK2,[8] Androgen receptor,[9][10][11] CREB-binding protein,[8][12] Glucocorticoid receptor,[13][14] Peroxisome proliferator-activated receptor gamma,[15] IKBKG,[8] Estrogen receptor alpha,[7][16][17] Estrogen receptor beta,[16][18] DDX5,[7] CHUK[8] and Retinoid X receptor alpha.[19][20]


External links

  • Medical Subject Headings (MeSH)
  • C91

Further reading

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.