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Nuclear receptor coactivator 3

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Title: Nuclear receptor coactivator 3  
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Subject: Histone acetyltransferase, AIB, Androgen receptor, Glucocorticoid receptor, Estrogen receptor alpha, IKBKG, CREB-binding protein, IKK2, Breast cancer classification
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Nuclear receptor coactivator 3

Nuclear receptor coactivator 3
PDB rendering based on 1kbh.
Available structures
PDB Ortholog search: RCSB
Identifiers
2.3.1.48
RNA expression pattern

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene.[1][2] NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Function

NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression.[3][4]

Clinical significance

The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment.[5][6]

Interactions

Nuclear receptor coactivator 3 has been shown to interact with DDX17,[7] IKK2,[8] Androgen receptor,[9][10][11] CREB-binding protein,[8][12] Glucocorticoid receptor,[13][14] Peroxisome proliferator-activated receptor gamma,[15] IKBKG,[8] Estrogen receptor alpha,[7][16][17] Estrogen receptor beta,[16][18] DDX5,[7] CHUK[8] and Retinoid X receptor alpha.[19][20]

References

External links

  • Medical Subject Headings (MeSH)
  • C91

Further reading

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