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Pelp-1

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Pelp-1

proline, glutamic acid and leucine rich protein 1
Identifiers
Symbol PELP1
Entrez 27043
HUGO 30134
OMIM 609455
RefSeq NM_014389
UniProt Q8IZL8
Other data
Locus Chr. 17 p13.2

PELP-1 (MNAR)[1] is a transcriptional corepressor for nuclear receptors such as glucocorticoid receptors[2] and a coactivator for estrogen receptors.[3]

Contents

  • Activation of protein kinases 1
  • Histone deacetylase 2
  • See also 3
  • External links 4
  • References 5

Activation of protein kinases

PELP-1 has been shown to bind to both estrogen receptor alpha and estrogen receptor beta.[3] It was also reported that protein tyrosine kinases of the src family can form a complex with estrogen receptors and PELP-1 and it was reported that when bound to PELP-1 and estrogen receptor alpha the kinase activity of SRC was activated in an estrogen-sensitive manner. Mitogen-activated protein kinases ERK1 and ERK2 were found to become phosphorylated in estrogen-treated cells containing PELP-1 . It was reported that the enhancement of estrogen-induced gene transcription due to PELP-1 could be blocked by protein kinase inhibitors. This suggested a model of PELP-1 function in which estrogen and PELP-1 cooperate to activate protein kinases which in turn activate gene transcription.

Histone deacetylase

When functioning as a corepressor of transcription PELP-1 recruits histone deacetylase.[2] Estrogen has been associated with stimulation of cell proliferation and progression of cells through G1 to the S phase of the cell cycle. The retinoblastoma protein (Rb) is a regulator of G1. It was reported that PELP-1 interacts with Rb.[4] It is not known if estrogen receptors can displace histone deacetylase from Rb.

See also

External links

  • protein, human/MB_cgi?mode=&term=PELP1+protein,+human PELP1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
  • NURSA }

References

  1. ^ Vadlamudi RK, Kumar R (2007). "Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR". Nuclear receptor signaling 5: e004.  
  2. ^ a b Choi YB, Ko JK, Shin J (December 2004). "The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains". J. Biol. Chem. 279 (49): 50930–41.  
  3. ^ a b Vadlamudi RK, Wang RA, Mazumdar A, et al. (October 2001). "Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha". J. Biol. Chem. 276 (41): 38272–9.  
  4. ^ Balasenthil S, Vadlamudi RK (June 2003). "Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein". J. Biol. Chem. 278 (24): 22119–27.  
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