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Title: Polr2a  
Author: World Heritage Encyclopedia
Language: English
Subject: Housekeeping gene, RNA polymerase II, TATA-binding protein, PCAF, CREB-binding protein
Publisher: World Heritage Encyclopedia


Polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

DNA-directed RNA polymerase II subunit RPB1 is an enzyme that in humans is encoded by the POLR2A gene.

This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA-binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.[1]


POLR2A has been shown to interact with Transcription elongation regulator 1,[2] CREB-binding protein,[3] BRCA1,[4][5][6][7] GTF2H4,[5] TATA-binding protein,[5] PCAF,[3] GTF2F1,[3][5] SUPT5H,[8][9] Transcription Factor II B,[5] POLR2H,[10] POLR2L,[10] MED26,[11] Cyclin-dependent kinase 8,[3] ZNF74,[12] TCEA1,[13][14][15] SMYD3,[16] CTDP1,[5] POLR2C,[10] PQBP1,[17] SMARCA2,[3][18][19] SND1,[20] MED21,[3][5][21] SMARCB1,[3][18][19] POLR2E,[10] SMARCA4[18][19][22] and TAF11.[5]


Further reading

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