Phosphatidylethanolamine N-methyltransferase

phosphatidylethanolamine N-methyltransferase
EC number CAS number IntEnz BRENDA ExPASy KEGG MetaCyc metabolic pathway
PRIAM PDB structures PDBsum
Gene Ontology EGO
phosphatidylethanolamine N-methyltransferase
Symbol PEMT
Entrez HUGO RefSeq EC number Locus p11.2

In chemical reaction

S-adenosyl-L-methionine + phosphatidylethanolamine \rightleftharpoons S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine

Thus, the two substrates of this enzyme are S-adenosyl methionine and phosphatidylethanolamine, whereas its two products are S-adenosylhomocysteine and phosphatidyl-N-methylethanolamine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase. Other names in common use include PEMT, LMTase, lipid methyl transferase, phosphatidylethanolamine methyltransferase, phosphatidylethanolamine-N-methylase, and phosphatidylethanolamine-S-adenosylmethionine methyltransferase. This enzyme participates in glycine, serine and threonine metabolism and glycerophospholipid metabolism.

See also


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