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Title: Smarca2  
Author: World Heritage Encyclopedia
Language: English
Subject: SWI/SNF
Publisher: World Heritage Encyclopedia


SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
PDB rendering based on 2dat.
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene.[1][2]

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.[2]


SMARCA2 has been shown to interact with SS18,[3] ACTL6A,[4][5][6] SIN3A,[7] POLR2A,[4][7][8] Prohibitin,[9] SMARCC1,[4][7] CEBPB,[10] SMARCB1[4][7] and ARID1B.[11]


Further reading

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