Staphylococcal nuclease and tudor domain containing 1
PDB rendering based on 2hqx.
Available structures
PDB Ortholog search: RCSB
SND1 Gene

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene.[1][2][3][4] SND1 is a main component of RISC complex[5] and plays an important role in miRNA function.[6][7] SND1 is Tudor Domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster.[8] SND1 is also involved in Autism.[9]

Clinical significance

SND1 acts as oncogene in many cancers[10][11][12] and in hepatocellular carcinoma progression.[6][7] SND1 promotes tumor angiogenesis in human hepatocellular carcinoma through a novel pathway which involves NF-kappaB and miR-221.[13]


SND1 has been shown to interact with PIM1,[14] STAT6,[15] RBPJ,[16][17] POLR2A[15] and MYB.[18]

SND1 also interacts with G3BP (stress granule protein)[19] and AEG-1.[6][7]


Further reading

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