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Title: Avpr2  
Author: World Heritage Encyclopedia
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Subject: Nephrogenic diabetes insipidus
Publisher: World Heritage Encyclopedia


Arginine vasopressin receptor 2
Available structures
PDB Ortholog search: RCSB
AVPR2 Gene

Arginine vasopressin receptor 2 (officially abbreviated AVPR2) is a protein that acts as receptor for arginine vasopressin.[1] AVPR2 belongs to the subfamily of G-protein-coupled receptors. Its activity is mediated by the Gs type of G proteins, which stimulate adenylate cyclase.

AVPR2 is expressed in the kidney tubule, predominantly in the membrane of cells of the distal convoluted tubule and collecting ducts, in fetal lung tissue and lung cancer, the last two being associated with alternative splicing. AVPR2 is also expressed outside the kidney, and, when stimulated, a variety of clotting factors are released into the bloodstream.

In the kidney, AVPR2's primary property is to respond to arginine vasopressin by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of AVPR2 is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results.


Vasopressin receptor antagonists that are selective for the V2 receptor include:

Their main uses are in hyponatremia, such as that caused by syndrome of inappropriate antidiuretic hormone (SIADH) and heart failure, however these agents should be avoided in patients with cirrhosis.[2]


Arginine vasopressin receptor 2 has been shown to interact with C1QTNF1.[3]


Further reading

External links

  • GeneReviews/NCBI/NIH/UW entry on Nephrogenic Diabetes Insipidus
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