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Title: Bach2  
Author: World Heritage Encyclopedia
Language: English
Subject: BZIP domain, NeuroD, EMX homeogene, NOBOX, Nur (biology)
Collection: Transcription Factors
Publisher: World Heritage Encyclopedia


BTB and CNC homology 1, basic leucine zipper transcription factor 2

Crystal structure of the human Bach2 BTB/POZ domain dimer. PDB entry [1]
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; BTBD25
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Transcription regulator protein BACH2 is a protein that in humans is encoded by the BACH2 gene.[2][3][4] It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer [5] and a bZip_Maf domain at the C-terminus.


  1. ^ Rosbrook, G. O.; Stead, M. A.; Carr, S. B.; Wright, S. C. (2011). "The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond". Acta Crystallographica Section D Biological Crystallography 68 (Pt 1): 26–34.  
  2. ^ Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T, Muto A, Nagai H, Kinoshita T, Yamamoto M, Inazawa J, Taketo MM, Nakahata T, Igarashi K, Yokoyama M (Sep 2000). "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15". Oncogene 19 (33): 3739–49.  
  3. ^ Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, Ikebe D, Igarashi K, Ito E (Oct 2003). "B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs". Blood 102 (9): 3317–22.  
  4. ^ "Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2". 
  5. ^ Rosbrook, G. O.; Stead, M. A.; Carr, S. B.; Wright, S. C. (2011). "The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond". Acta Crystallographica Section D Biological Crystallography 68 (Pt 1): 26–34.  

Further reading

  • Oyake T, Itoh K, Motohashi H, et al. (1996). "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site.". Mol. Cell. Biol. 16 (11): 6083–95.  
  • Kobayashi A, Yamagiwa H, Hoshino H, et al. (2000). "A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain.". Mol. Cell. Biol. 20 (5): 1733–46.  
  • Hoshino H, Kobayashi A, Yoshida M, et al. (2000). "Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element.". J. Biol. Chem. 275 (20): 15370–6.  
  • Vieira SA, Deininger MW, Sorour A, et al. (2002). "Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene.". Genes Chromosomes Cancer 32 (4): 353–63.  
  • Muto A, Tashiro S, Tsuchiya H, et al. (2002). "Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies.". J. Biol. Chem. 277 (23): 20724–33.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11.  
  • Takakuwa T, Luo WJ, Ham MF, et al. (2004). "Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression.". Am. J. Pathol. 164 (3): 967–74.  
  • Tashiro S, Muto A, Tanimoto K, et al. (2004). "Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2.". Mol. Cell. Biol. 24 (8): 3473–84.  
  • Motamed-Khorasani A, Jurisica I, Letarte M, et al. (2007). "Differentially androgen-modulated genes in ovarian epithelial cells from BRCA mutation carriers and control patients predict ovarian cancer survival and disease progression.". Oncogene 26 (2): 198–214.  
  • Yoshida C, Yoshida F, Sears DE, et al. (2007). "Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1.". Blood 109 (3): 1211–9.  
  • Ono A, Kono K, Ikebe D, et al. (2007). "Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells.". Genes Chromosomes Cancer 46 (1): 67–74.  
  • Ikeda T, Shibata J, Yoshimura K, et al. (2007). "Recurrent  
  • Hoshino H, Nishino TG, Tashiro S, et al. (2007). "Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression.". J. Biochem. 141 (5): 719–27.  

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