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Title: Cdk8  
Author: World Heritage Encyclopedia
Language: English
Subject: Mediator (coactivator), Let-7 microRNA precursor
Publisher: World Heritage Encyclopedia


Cyclin-dependent kinase 8
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene.[1][2]

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.[2]See also Protein kinase domain to view the more general properties of kinases.


Cyclin-dependent kinase 8 has been shown to interact with MED16,[3][4] MED26,[5] MED17,[3][4] MED14,[3][6] CREB binding protein,[7] MED1,[3][4] MED6,[3][4][6][8] MED24,[3][4] CCNC,[1][4][6][7][9] POLR2A,[7] MED21,[3][4][7][10] SMARCB1,[7] MED12[3][4] and CRSP3.[4][6]


Further reading

External links

  • Medical Subject Headings (MeSH)

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