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CDP-diacylglycerol—serine O-phosphatidyltransferase

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Title: CDP-diacylglycerol—serine O-phosphatidyltransferase  
Author: World Heritage Encyclopedia
Language: English
Subject: Kinases, RNA polymerase IV, RNase PH, Diphosphotransferase, Class II PI 3-kinases
Collection: Ec 2.7.8, Enzymes of Unknown Structure
Publisher: World Heritage Encyclopedia

CDP-diacylglycerol—serine O-phosphatidyltransferase

CDP-diacylglycerol-serine O-phosphatidyltransferase
EC number
CAS number 9068-48-8
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a CDP-diacylglycerol—serine O-phosphatidyltransferase (EC is an enzyme that catalyzes the chemical reaction

CDP-diacylglycerol + L-serine \rightleftharpoons CMP + (3-sn-phosphatidyl)-L-serine

Thus, the two substrates of this enzyme are CDP-diacylglycerol and L-serine, whereas its two products are CMP and (3-sn-phosphatidyl)-L-serine.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-diacylglycerol:L-serine 3-sn-phosphatidyltransferase. Other names in common use include phosphatidylserine synthase, CDPdiglyceride-serine O-phosphatidyltransferase, PS synthase, cytidine 5'-diphospho-1,2-diacyl-sn-glycerol, (CDPdiglyceride):L-serine O-phosphatidyltransferase, phosphatidylserine synthetase, CDP-diacylglycerol-L-serine O-phosphatidyltransferase, cytidine diphosphoglyceride-serine O-phosphatidyltransferase, CDP-diglyceride-L-serine phosphatidyltransferase, CDP-diglyceride:serine phosphatidyltransferase, cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine, O-phosphatidyltransferase, and CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase. This enzyme participates in glycine, serine and threonine metabolism and glycerophospholipid metabolism.


  • Larson TJ, Dowhan W (1976). "Ribosomal-associated phosphatidylserine synthetase from Escherichia coli: purification by substrate-specific elution from phosphocellulose using cytidine 5'-diphospho-1,2-diacyl-sn-glycerol". Biochemistry. 15 (24): 5212–8.  
  • Raetz CR, Kennedy EP (1974). "Partial purification and properties of phosphatidylserine synthetase from Escherichia coli". J. Biol. Chem. 249 (16): 5083–45.  

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