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Cebpa

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Cebpa

CCAAT/enhancer binding protein (C/EBP), alpha

PDB rendering based on .[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; C/EBP-alpha; CEBP
External IDs GeneCards:
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

CCAAT/enhancer-binding protein alpha is a protein that in humans is encoded by the CEBPA gene.[2][3]

Function

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.[4]

Interactions

CEBPA has been shown to interact with Cyclin-dependent kinase 2[5] and Cyclin-dependent kinase 4.[5]

Clinical significance

It has been shown that mutation of CEBPA has been linked to good outcome in both adult and pediatric acute myeloid leukemia patients.[6]

See also

Ccaat-enhancer-binding proteins

References

  1. ^ Miller, M; Shuman, J. D.; Sebastian, T; Dauter, Z; Johnson, P. F. (2003). "Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein alpha". Journal of Biological Chemistry 278 (17): 15178–84.  
  2. ^ Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (July 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics 13 (2): 293–300.  
  3. ^ Cao Z, Umek RM, McKnight SL (October 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes Dev 5 (9): 1538–52.  
  4. ^ "Entrez Gene: CEBPA CCAAT/enhancer binding protein (C/EBP), alpha". 
  5. ^ a b Wang H, Iakova P, Wilde M, Welm A, Goode T, Roesler WJ, Timchenko NA (October 2001). "C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4". Mol. Cell 8 (4): 817–28.  
  6. ^ Ho PA, Alonzo TA, Gerbing RB, Pollard J, Stirewalt DL, Hurwitz C, Heerema NA, Hirsch B, Raimondi SC, Lange B, Franklin JL, Radich JP, Meshinchi S (June 2009). "Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group". Blood 113 (26): 6558–66.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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