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Title: Campylobacteriosis  
Author: World Heritage Encyclopedia
Language: English
Subject: Chicken, United States raw milk debate, Campylobacter jejuni, List of infectious diseases, Foodborne illnesses
Collection: Bacterial Diseases, Foodborne Illnesses, Gi Tract Disorders, Poultry Diseases
Publisher: World Heritage Encyclopedia


Classification and external resources
Specialty Infectious disease
ICD-10 A04.5
ICD-9-CM 008.43
DiseasesDB 1914
MedlinePlus 000224
eMedicine ped/2697 med/263
MeSH D002169

Campylobacteriosis is an infection by the Campylobacter bacterium,[1] most commonly C. jejuni. It is among the most common bacterial infections of humans, often a foodborne illness. It produces an inflammatory, sometimes bloody, diarrhea or dysentery syndrome, mostly including cramps, fever and pain.


  • Cause 1
  • Transmission 2
  • Epidemiology 3
  • Symptoms 4
    • Other factors 4.1
  • Diagnosis 5
  • Treatment 6
    • Antibiotics 6.1
    • In animals 6.2
  • Prognosis 7
    • Complications 7.1
  • Prevention 8
  • See also 9
  • References 10
  • External links 11


Campylobacter bacteria are the number-one cause of food-related gastrointestinal illness in the United States. This scanning electron microscope image shows the characteristic spiral, or corkscrew, shape of C. jejuni cells and related structures.

Campylobacteriosis is caused by Campylobacter bacteria (curved or spiral, motile, non–spore-forming, Gram-negative rods). The disease is usually caused by C. jejuni, a spiral and comma shaped bacterium normally found in cattle, swine, and birds, where it is nonpathogenic, but the illness can also be caused by C. coli (also found in cattle, swine, and birds), C. upsaliensis (found in cats and dogs) and C. lari (present in seabirds in particular).

One effect of campylobacteriosis is tissue injury in the gut. The sites of tissue injury include the jejunum, the ileum, and the colon. C jejuni appears to achieve this by invading and destroying epithelial cells.

C. jejuni can also cause a latent autoimmune effect on the nerves of the legs, which is usually seen several weeks after a surgical procedure of the abdomen. The effect is known as an acute idiopathic demyelinating polyneuropathy (AIDP), i.e. Guillain–Barré syndrome, in which one sees symptoms of ascending paralysis, dysaesthesias usually below the waist, and, in the later stages, respiratory failure.

Some strains of C jejuni produce a hemolytic uremic syndrome and thrombotic thrombocytopenic purpura through a poorly understood mechanism.


The common routes of transmission for the disease-causing bacteria are fecal-oral, person-to-person sexual contact, ingestion of contaminated food (generally unpasteurized (raw) milk and undercooked or poorly handled poultry), and waterborne (i.e., through contaminated drinking water). Contact with contaminated poultry, livestock, or household pets, especially puppies, can also cause disease.[2]

Animals farmed for meat are the main source of campylobacteriosis. A study published in PLoS Genetics (September 26, 2008) by researchers from Lancashire, England, and Chicago, Illinois, found that 97 percent of campylobacteriosis cases sampled in Lancashire were caused by bacteria typically found in chicken and livestock. In 57 percent of cases, the bacteria could be traced to chicken, and in 35 percent to cattle. Wild animal and environmental sources were accountable for just three percent of disease.[3][4]

The infectious dose is 1000–10,000 bacteria (although ten to five hundred bacteria can be enough to infect humans). Campylobacter species are sensitive to hydrochloric acid in the stomach, and acid reduction treatment can reduce the amount of inoculum needed to cause disease.

Exposure to bacteria is often more common during travelling, and therefore campylobacteriosis is a common form of travelers' diarrhea.


Campylobacter is one of the most common causes of human bacterial gastroenteritis.[5] For instance, an estimated 2 million cases of Campylobacter enteritis occur annually in the U.S., accounting for 5–7% of cases of gastroenteritis. Furthermore, in the United Kingdom during 2000, Campylobacter jejuni was involved in 77.3% in all cases of laboratory confirmed foodborne illness.[6] About 15 of every 100,000 people are diagnosed with campylobacteriosis every year, and with many cases going unreported, up to 0.5% of the general population may unknowingly harbor Campylobacter in their gut.

A large animal reservoir is present as well, with up to 100% of poultry, including chickens, turkeys, and waterfowl, having asymptomatic infections in their intestinal tracts. Infected chicken feces may contain up to 109 bacteria per 25 grams, and due to the installations, the bacteria are rapidly spread to other chickens. This vastly exceeds the infectious dose of 1000–10,000 bacteria for humans.

In January 2013, the UK's Food Standards Agency warned that two-thirds of all raw chicken bought from UK shops was contaminated with campylobacter, affecting an estimated half a million people annually and killing approximately 100.[7]


The prodrome is fever, headache, and myalgia, lasting as long as 24 hours. The actual latent period is 2–5 days (sometimes 1–6 days). In other words, it typically takes 1–2 days until actual symptoms develop. These are diarrhea (as many as 10 watery, frequently bloody, bowel movements per day) or dysentery, cramps, abdominal pain, and fever as high as 40 °C (104 °F). In most people, the illness lasts for 2–10 days. This is classified as invasive/inflammatory diarrhea, also known as bloody diarrhea or dysentery.

Symptoms may also depend on route of transmission. In participants of unprotected anal intercourse, campylobacteriosis is more localized to the distal end of the colon and may be termed a proctocolitis.

There are other diseases showing similar symptoms. For instance, abdominal pain and tenderness may be very localized, mimicking acute appendicitis. Furthermore, Helicobacter pylori is closely related to Campylobacter and causes peptic ulcer disease.

Other factors

In patients with HIV, infections may be more frequent, may cause prolonged bouts of dirty brown diarrhea, and may be more commonly associated with bacteremia and antibiotic resistance. The severity and persistence of infection in patients with AIDS and hypogammaglobulinemia indicates that both cell-mediated and humoral immunity are important in preventing and terminating infection.


Campylobacter organisms can be detected by performing a Gram stain of a stool sample with high EIA or PCR.


The infection is usually self-limiting, and in most cases, symptomatic treatment by liquid and electrolyte replacement is enough in human infections.[8]


Antibiotic treatment is controversial, and has only a marginal benefit (1.32 days) on the duration of symptoms, and should not be used routinely.[9]

  • Campylobacter jejuni genomes and related information at PATRIC, a Bioinformatics Resource Center funded by NIAID

External links

  1. ^ Centers for disease Control and Prevention
  2. ^
  3. ^ Animals Farmed for Meat Are the Number 1 Source of Food Poisoning Bug Newswise, Retrieved on September 23, 2008.
  4. ^
  5. ^ Moore, 2005
  6. ^ Food Standards Agency
  7. ^
  8. ^ Sherris
  9. ^
  10. ^
  11. ^
  12. ^ Medical microbiology,Murray, P.R. and others. 2002 Mosby St. Louis
  13. ^


See also

  • Food should be properly cooked and hot when served.
  • Consume only pasteurized or boiled milk and milk products, never raw milk products.
  • Make sure that ice is from safe water.
  • If you are not sure of the safety of drinking water, boil it, or disinfect it with chemical disinfectant.
  • Wash hands thoroughly and frequently with soap, especially after using the toilet and after contact with pets and farm animals.
  • Wash fruits and vegetables thoroughly, especially if they are to be eaten raw. Peel fruits and vegetables whenever possible.
  • Food handlers, professionals and at home, should observe hygienic rules during food preparation.
  • Professional food handlers should immediately report to their employer any fever, diarrhea, vomiting or visible infected skin lesions.

The World Health Organization recommends the following:[13]

  • Pasteurization of milk and chlorination of drinking water destroy the organism.
  • Treatment with antibiotics can reduce fecal excretion.
  • Infected health care workers should not provide direct patient care.
  • Separate cutting boards should be used for foods of animal origin and other foods. After preparing raw food of animal origin, all cutting boards and countertops should be carefully cleaned with soap and hot water.
  • Contact with pet saliva and feces should be avoided.


Some individuals (1–2 in 100,000 cases) develop Guillain–Barré syndrome, in which the nerves that join the spinal cord and brain to the rest of the body are damaged, sometimes permanently. This occurs only with infection of C. jejuni and C. upsaliensis.[12]

Occasional deaths occur in young, previously healthy individuals because of blood volume depletion (due to dehydration), and in persons who are elderly or immunocompromised.

Complications include toxic megacolon, dehydration and sepsis. Such complications generally occur in young children (< 1 year of age) and immunocompromised people. A chronic course of the disease is possible; this disease process is likely to develop without a distinct acute phase. Chronic campylobacteriosis features a long period of sub-febrile temperature and asthenia; eye damage, arthritis, endocarditis may develop if infection is untreated.


Campylobacteriosis is usually self-limited without any mortality (assuming proper hydration is maintained). However, there are several possible complications.


Currently growing resistance of the Campylobacter to fluoroquinolones and macrolides is of a major concern.

In the past, poultry infections were often treated by mass administration of enrofloxacin and sarafloxacin for single instances of infection. The FDA banned this practice, as it promoted the development of fluoroquinolone-resistant populations.[11] A major broad-spectrum fluoroquinolone used in humans is ciprofloxacin.

In animals

Antimotility agents, such as loperamide, can lead to prolonged illness or intestinal perforation in any invasive diarrhea, and should be avoided. Trimethoprim/sulfamethoxazole and ampicillin are ineffective against Campylobacter.


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