World Library  
Flag as Inappropriate
Email this Article

Chromosome 15q partial deletion

Article Id: WHEBN0000088863
Reproduction Date:

Title: Chromosome 15q partial deletion  
Author: World Heritage Encyclopedia
Language: English
Subject: Prader–Willi syndrome, Epigenetics
Publisher: World Heritage Encyclopedia

Chromosome 15q partial deletion

Chromosome 15q partial deletion is an extremely rare human genetic disorder, caused by a chromosomal aberration in which the long ("q") arm of one copy of chromosome 15 is deleted, or partially deleted. If the mother's copy of the chromosomal arm is deleted, Angelman syndrome results. If the father's copy of the chromosomal arm is deleted, Prader-Willi syndrome results. The smallest observed region that can result in these syndromes when deleted is therefore called the PWS/AS critical region and is situated at 15q11-q13. In addition to deletions, uniparental disomy of chromosome 15 gives rise to the same genetic disorders, indicating that genomic imprinting must occur in this region.

See also

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.