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Differentiation-inducing factor

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Title: Differentiation-inducing factor  
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Differentiation-inducing factor

Differentiation-inducing factor (DIF) is one of a class of effector molecules that induce changes in cell chemistry, inhibiting growth and promoting differentiation of cell type. DIFs 1-3 are chlorinated hexaphenones (phenylalkan-1-ones, with chloro, hydroxy and methoxy substitution on the benzene ring), and have been isolated from Dictyostelium discoideum slime mold. DIFs have been of interest because of their tumor inhibiting properties. DIFs have also been used to help regulate plant growth.

In Dictyostelium the DIF Factor stimulates the formation of certain cell types.


  • Masento MS, Morris HR, Taylor GW, Johnson SJ, Skapski AC, Kay RR (November 1988). and its analogues. Synthesis, structure and biological activity"Dictyostelium discoideum"Differentiation-inducing factor from the slime mould . Biochem. J. 256 (1): 23–8. PMC 1135362. PMID 3223901. 
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