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Ercc5

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Subject: Xeroderma pigmentosum, Cancer research, Nucleotide excision repair, ERCC2
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Ercc5

Excision repair cross-complementing rodent repair deficiency, complementation group 5
Identifiers
ERCC5 Gene
RNA expression pattern

DNA repair protein complementing XP-G cells is a protein that in humans is encoded by the ERCC5 gene.[1][2]

Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G) is involved in excision repair of UV-induced DNA damage. Mutations cause Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been described, but the biological validity of all variants has not been determined.[2]

Interactions

ERCC5 has been shown to interact with ERCC2.[3]

References

External links

  • GeneReviews/NIH/NCBI/UW entry on Xeroderma Pigmentosum

Further reading



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