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Subject: BRCA2, Cancer research
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Fanconi anemia, complementation group G
RNA expression pattern

Fanconi anemia group G protein is a protein that in humans is encoded by the FANCG gene.[1][2][3]


FANCG, involved in Fanconi anemia, confers resistance to both hygromycin B and mitomycin C. FANCG contains a 5-prime GC-rich untranslated region characteristic of housekeeping genes. The putative 622-amino acid protein has a leucine-zipper motif at its N-terminus. Fanconi anemia is an autosomal recessive disorder with diverse clinical symptoms, including developmental anomalies, bone marrow failure, and early occurrence of malignancies. A minimum of 8 FA genes have been identified. The FANCG gene is responsible for complementation group G.[3]


FANCG has been shown to interact with FANCF,[4][5][6][7]

FANCA,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] FANCE[7][21][24] and BRCA2.[25]


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