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Title: Fosl1  
Author: World Heritage Encyclopedia
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Subject: FOSB, USF1, BZIP domain, NeuroD, EMX homeogene
Collection: Transcription Factors
Publisher: World Heritage Encyclopedia


FOS-like antigen 1
Symbols  ; FRA; FRA1; fra-1
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Fos-related antigen 1 is a protein that in humans is encoded by the FOSL1 gene.[1][2] The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[2]


  • Interactions 1
  • See also 2
  • References 3
  • Further reading 4
  • External links 5


FOSL1 has been shown to interact with USF1 (human gene)[3] and C-jun.[3]

See also


  1. ^ Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (Apr 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene 5 (3): 249–55.  
  2. ^ a b "Entrez Gene: FOSL1 FOS-like antigen 1". 
  3. ^ a b Pognonec, P; Boulukos K E; Aperlo C; Fujimoto M; Ariga H; Nomoto A; Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene (ENGLAND) 14 (17): 2091–8.  

Further reading

  • Herdegen T, Leah JD (1999). "Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.". Brain Res. Brain Res. Rev. 28 (3): 370–490.  
  • Reddy SP, Mossman BT (2002). "Role and regulation of activator protein-1 in toxicant-induced responses of the lung.". Am. J. Physiol. Lung Cell Mol. Physiol. 283 (6): L1161–78.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4.  
  • Tsuchiya H, Fujii M, Niki T, et al. (1993). "Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals". J. Virol. 67 (12): 7001–7.  
  • Sinke RJ, Tanigami A, Nakamura Y, Geurts van Kessel A (1994). "Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13". Genomics 18 (1): 165.  
  • Courseaux A, Grosgeorge J, Gaudray P, et al. (1997). "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1)". Genomics 37 (3): 354–65.  
  • Arts J, Herr I, Lansink M, et al. (1997). "Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro". Nucleic Acids Res. 25 (2): 311–7.  
  • Pognonec P, Boulukos KE, Aperlo C, et al. (1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene 14 (17): 2091–8.  
  • Smith CM, Ma NS, Nowak NJ, et al. (1997). "A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13". Genome Res. 7 (8): 835–42.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56.  
  • Puntschart A, Wey E, Jostarndt K, et al. (1998). "Expression of fos and jun genes in human skeletal muscle after exercise". Am. J. Physiol. 274 (1 Pt 1): C129–37.  
  • Finzer P, Soto U, Delius H, et al. (2000). "Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition". Oncogene 19 (29): 3235–44.  
  • Udalova IA, Kwiatkowski D (2001). "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region". Biochem. Biophys. Res. Commun. 289 (1): 25–33.  
  • Jardine H, MacNee W, Donaldson K, Rahman I (2002). "Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1". J. Biol. Chem. 277 (24): 21158–66.  
  • Wang HL, Wang J, Xiao SY, et al. (2002). "Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin". Int. J. Cancer 101 (4): 301–10.  
  • Bergman MR, Cheng S, Honbo N, et al. (2003). "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers". Biochem. J. 369 (Pt 3): 485–96.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  

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