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Title: Foxg1  
Author: World Heritage Encyclopedia
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Subject: JARID1B, Retina, NeuroD, EMX homeogene, NOBOX
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Forkhead box G1
Symbols  ; BF1; BF2; FHKL3; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; FOXG1A; FOXG1B; FOXG1C; HBF-1; HBF-2; HBF-3; HBF-G2; HBF2; HFK1; HFK2; HFK3; KHL2; QIN
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Forkhead box protein G1 is a protein that in humans is encoded by the FOXG1 gene.[1][2][3] This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of the brain and telencephalon.[3]

Much more research is needed to understand the impacts and effects of mutations of this group of genes. There are currently some research studies on Fox g1 underway at the University of Rochester, and at Azienda Ospedaliera Universitaria Senese, Italy. At the close of 2012, The International Fox G1 Foundation was created, and is working to secure funding for the development of a research mouse. For more information, and to help in these efforts, please visit

See also


FOXG1 has been shown to interact with JARID1B.[4]


  1. ^ Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei MG, Schulz-Schaeffer W, Thies U (Nov 1994). "Human brain factor 1, a new member of the fork head gene family". Genomics 21 (3): 551–7.  
  2. ^ Bredenkamp N, Seoighe C, Illing N (Feb 2007). "Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation". Dev Genes Evol 217 (3): 227–33.  
  3. ^ a b "Entrez Gene: FOXG1B forkhead box G1B". 
  4. ^ Tan, Keith; Shaw Anthony L, Madsen Bente, Jensen Kirsten,

Further reading

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