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Gabpa

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Title: Gabpa  
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Gabpa

GA binding protein transcription factor, alpha subunit 60kDa

PDB rendering based on 1awc.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A; RCH04A07
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene.[1] This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype.[2]

Interactions

GABPA has been shown to interact with Host cell factor C1,[3] Sp1 transcription factor[4] and Sp3 transcription factor.[4]

References

  1. ^ Watanabe H, Sawada J, Yano K, Yamaguchi K, Goto M, Handa H (April 1993). "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs". Mol Cell Biol 13 (3): 1385–91.  
  2. ^ "Entrez Gene: GABPA GA binding protein transcription factor, alpha subunit 60kDa". 
  3. ^ Vogel, J L; Kristie T M (February 2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". EMBO J. (ENGLAND) 19 (4): 683–90.  
  4. ^ a b Galvagni, F; Capo S; Oliviero S (March 2001). "Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter". J. Mol. Biol. (England) 306 (5): 985–96.  

Further reading

External links


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