General transcription factors

General transcription factors (GTFs), also known as basal transcriptional factors, are a class of protein transcription factors that bind to specific sites on DNA to activate transcription. GTFs, RNA polymerase, and the mediator multiple protein complex constitute the basic transcriptional apparatus.[1] GTFs are also intimately involved in the process of gene regulation, and most are required for life.[2]

Types

In bacteria, transcription initiation requires an RNA polymerase and a single GTF: sigma factor.

In archaea and eukaryotes, transcription initiation requires an RNA polymerase and a set of multiple GTFs. The Transcription initiation by eukaryotic RNA polymerase II involves the following GTFs:[3][4]

References

External links

  • Medical Subject Headings (MeSH)

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