World Library  
Flag as Inappropriate
Email this Article

Guanosine triphosphate

Article Id: WHEBN0000396089
Reproduction Date:

Title: Guanosine triphosphate  
Author: World Heritage Encyclopedia
Language: English
Subject: Chloroplast DNA, Importin, Adenosine triphosphate, G protein, Cyclic guanosine monophosphate
Collection: Nucleotides, Purines
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Guanosine triphosphate

Guanosine triphosphate
Skeletal formula of guanosine triphosphate
Space-filling model of the guanosine triphosphate anion
Names
IUPAC name
((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
Other names
guanosine triphosphate, 9-β-D-ribofuranosylguanine-5'-triphosphate, 9-β-D-ribofuranosyl-2-amino-6-oxo-purine-5'-triphosphate
Identifiers
 Y
ChEBI  Y
ChemSpider  Y
Jmol-3D images Image
KEGG  N
MeSH
PubChem
Properties
C10H16N5O14P3
Molar mass 523.18 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N  (: Y/N?)

Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate. It can act as a substrate for the synthesis of RNA during the transcription process or DNA during DNA replication. Its structure is similar to that of the guanine nucleobase, the only difference being that nucleotides like GTP have a ribose sugar and three phosphates, with the nucleobase attached to the 1' and the triphosphate moiety attached to the 5' carbons of the ribose.

It also has the role of a source of energy or an activator of substrates in metabolic reactions, like that of ATP, but more specific. It is used as a source of energy for protein synthesis and gluconeogenesis.

GTP is essential to signal transduction, in particular with G-proteins, in second-messenger mechanisms where it is converted to guanosine diphosphate (GDP) through the action of GTPases.

Contents

  • Uses 1
    • Energy transfer 1.1
    • Genetic translation 1.2
    • Microtubule dynamic instability 1.3
    • Mitochondrial Function 1.4
  • Biosynthesis 2
  • cGTP 3
  • See also 4
  • References 5
  • External links 6

Uses

Energy transfer

GTP is involved in energy transfer within the cell. For instance, a GTP molecule is generated by one of the enzymes in the citric acid cycle. This is tantamount to the generation of one molecule of ATP, since GTP is readily converted to ATP with nucleoside-diphosphate kinase (NDK).[1]

Genetic translation

During the elongation stage of translation, GTP is used as an energy source for the binding of a new amino-bound tRNA to the A site of the ribosome. GTP is also used as an energy source for the translocation of the ribosome towards the 3' end of the mRNA.[2]

Microtubule dynamic instability

During microtubule polymerization, each heterodimer formed by an alpha and a beta tubulin molecule carries two GTP molecules, and the GTP is hydrolyzed to GDP when the tubulin dimers are added to the plus end of the growing microtubule. Such GTP hydrolysis is not mandatory for microtubule formation, but it appears that only GDP-bound tubulin molecules are able to depolymerize. Thus, a GTP-bound tubulin serves as a cap at the tip of microtubule to protect from depolymerization; and, once the GTP is hydrolyzed, the microtubule begins to depolymerize and shrink rapidly.[3]

Mitochondrial Function

The translocation of proteins into the mitochondria matrix involves the interactions of both GTP and ATP. The importing of these proteins plays an important role in several pathways regulated within the mitochondria organelle.[4]

Biosynthesis

In the cell, GTP is synthesised through many processes including:

cGTP

Cyclic guanosine triphosphate (cGTP) helps cyclic adenosine monophosphate (cAMP) activate cyclic nucleotide-gated ion channels in the olfactory system.[5]

See also

References

  1. ^ a b c Berg, JM; JL Tymoczko; L Stryer (2002). Biochemistry (5th ed.). WH Freeman and Company. p. 476.  
  2. ^ Solomon, EP; LR Berg; DW Martin (2005). Biology (7th ed.). pp. 244–245. 
  3. ^ Gwen V. Childs. "Microtubule structure". cytochemistry.net. 
  4. ^ Sepuri, Naresh Babu V.; Norbert Schülke; Debkumar Pain (16 January 1998). "GTP Hydrolysis Is Essential for Protein Import into the Mitochondrial Matrix". Journal of Biological Chemistry (273): 1420–1424.  
  5. ^ Boron & Boulpaep (2005). Medical Physiology (Updated ed.). Elsevier Saunders. p. 90.  

External links

  • GTP bound to proteins in the PDB
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.