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H1foo

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H1foo

H1 histone family, member O, oocyte-specific
Identifiers
H1FOO Gene
Orthologs
SpeciesHumanMouse

Histone H1oo is a protein that in humans is encoded by the H1FOO gene.[1][2]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.[2]

It incorporates into sperm chromatin after fertilisation.[3]

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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