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Title: Hmgn1  
Author: World Heritage Encyclopedia
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Subject: NeuroD, EMX homeogene, Engrailed (gene), HOXC8, HOXD8
Publisher: World Heritage Encyclopedia


High mobility group nucleosome binding domain 1
Symbols  ; HMG14
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Non-histone chromosomal protein HMG-14 is a protein that in humans is encoded by the HMGN1 gene.[1][2][3] Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[supplied by OMIM][3]


HMGN1 has been shown to interact with YWHAZ.[4]


  1. ^ Landsman D, Srikantha T, Westermann R, Bustin M (Jan 1987). "Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family". J Biol Chem 261 (34): 16082–6.  
  2. ^ Landsman D, McBride OW, Soares N, Crippa MP, Srikantha T, Bustin M (Mar 1989). "Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family". J Biol Chem 264 (6): 3421–7.  
  3. ^ a b "Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1". 
  4. ^ Prymakowska-Bosak, Marta; Hock Robert; Catez Frédéric; Lim Jae-Hwan; Birger Yehudit; Shirakawa Hitoshi; Lee Kyung; Bustin Michael (Oct 2002). "Mitotic Phosphorylation of Chromosomal Protein HMGN1 Inhibits Nuclear Import and Promotes Interaction with 14.3.3 Proteins". Mol. Cell. Biol. (United States) 22 (19): 6809–19.  

Further reading

  • Pash J, Popescu N, Matocha M et al. (1990). "Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16". Proc. Natl. Acad. Sci. U.S.A. 87 (10): 3836–40.  
  • Leffak M, Trempe JP (1985). "Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus". Nucleic Acids Res. 13 (13): 4853–69.  
  • Postnikov YV, Trieschmann L, Rickers A, Bustin M (1995). "Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores". J. Mol. Biol. 252 (4): 423–32.  
  • Ding HF, Rimsky S, Batson SC et al. (1994). "Stimulation of RNA polymerase II elongation by chromosomal protein HMG-14". Science 265 (5173): 796–9.  
  • Pash JM, Alfonso PJ, Bustin M (1993). "Aberrant expression of high mobility group chromosomal protein 14 affects cellular differentiation". J. Biol. Chem. 268 (18): 13632–8.  
  • Bustin M, Alfonso PJ, Pash JM et al. (1996). "Characterization of transgenic mice with an increased content of chromosomal protein HMG-14 in their chromatin". DNA Cell Biol. 14 (12): 997–1005.  
  • Hock R, Scheer U, Bustin M (1999). "Chromosomal Proteins HMG-14 and HMG-17 Are Released from Mitotic Chromosomes and Imported into the Nucleus by Active Transport". J. Cell Biol. 143 (6): 1427–36.  
  • Louie DF, Gloor KK, Galasinski SC et al. (2000). "Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry". Protein Sci. 9 (1): 170–9.  
  • Bergel M, Herrera JE, Thatcher BJ et al. (2000). "Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes". J. Biol. Chem. 275 (15): 11514–20.  
  • Hattori M, Fujiyama A, Taylor TD et al. (2000). "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9.  
  • Prymakowska-Bosak M, Misteli T, Herrera JE et al. (2001). "Mitotic Phosphorylation Prevents the Binding of HMGN Proteins to Chromatin". Mol. Cell. Biol. 21 (15): 5169–78.  
  • Prymakowska-Bosak M, Hock R, Catez F et al. (2002). "Mitotic Phosphorylation of Chromosomal Protein HMGN1 Inhibits Nuclear Import and Promotes Interaction with 14.3.3 Proteins". Mol. Cell. Biol. 22 (19): 6809–19.  
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Soloaga A, Thomson S, Wiggin GR et al. (2003). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". EMBO J. 22 (11): 2788–97.  
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5.  
  • Zou Y, Jiang X, Wang Y (2004). "Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells". Biochemistry 43 (20): 6322–9.  
  • Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5.  
  • Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.  

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