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Hnf1a

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Title: Hnf1a  
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Subject: Hepatocyte nuclear factors, Hepatocyte nuclear factor 4 alpha, Neurogenins, Transcription factor, MODY 3
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Hnf1a

HNF1 homeobox A

PDB rendering based on 1ic8.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; HNF-1A; HNF1; IDDM20; LFB1; MODY3; TCF-1; TCF1
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene.[1][2]

The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes.[3]

Contents

  • Interactions 1
  • See also 2
  • References 3
  • Further reading 4

Interactions

HNF1A has been shown to interact with PCAF,[7] Src,[7] RAC3,[7] EP300,[8] CREB-binding protein[7] and PCBD1.[9][10]

See also

References

  1. ^ Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (June 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics 13 (2): 293–300.  
  2. ^ Vaxillaire M, Boccio V, Philippi A, Vigouroux C, Terwilliger J, Passa P, Beckmann JS, Velho G, Lathrop GM, Froguel P (April 1995). "A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q". Nat. Genet. 9 (4): 418–23.  
  3. ^ Courtois G, Morgan JG, Campbell LA, Fourel G, Crabtree GR (October 1987). "Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters". Science 238 (4827): 688–92.  
  4. ^ Hines RN, Luo Z, Cresteil T, Ding X, Prough RA, Fitzpatrick JL, Ripp SL, Falkner KC, Ge NL, Levine A, Elferink CJ (May 2001). "Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors". Drug Metab. Dispos. 29 (5): 623–33.  
  5. ^ Rufibach LE, Duncan SA, Battle M, Deeb SS (July 2006). "Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter". J. Lipid Res. 47 (7): 1463–77.  
  6. ^ a b Bulla GA, Kraus DM (December 2004). "Dissociation of the hepatic phenotype from HNF4 and HNF1alpha expression". Biosci. Rep. 24 (6): 595–608.  
  7. ^ a b c d Soutoglou, E; Papafotiou G; Katrakili N; Talianidis I (April 2000). "Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins". J. Biol. Chem. (UNITED STATES) 275 (17): 12515–20.  
  8. ^ Ban, Nobuhiro; Yamada Yuichiro; Someya Yoshimichi; Miyawaki Kazumasa; Ihara Yu; Hosokawa Masaya; Toyokuni Shinya; Tsuda Kinsuke; Seino Yutaka (May 2002). "Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter". Diabetes (United States) 51 (5): 1409–18.  
  9. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89.  
  10. ^ Sourdive, D J; Transy C; Garbay S; Yaniv M (April 1997). "The bifunctional DCOH protein binds to HNF1 independently of its 4-alpha-carbinolamine dehydratase activity". Nucleic Acids Res. (ENGLAND) 25 (8): 1476–84.  

Further reading

  • Eastman Q, Grosschedl R (1999). "Regulation of LEF-1/TCF transcription factors by Wnt and other signals". Curr. Opin. Cell Biol. 11 (2): 233–40.  
  • Bioulac-Sage P, Blanc JF, Rebouissou S, et al. (2007). "Genotype phenotype classification of hepatocellular adenoma". World J. Gastroenterol. 13 (19): 2649–54.  


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