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Hoxb13

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Title: Hoxb13  
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Hoxb13

Homeobox B13

PDB rendering based on 2cra.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; PSGD
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Homeobox protein Hox-B13 is a protein that in humans is encoded by the HOXB13 gene.[1][2][3] This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster on chromosome 17 in the 17q21-22 region.[3] Men who inherit a rare (<0.1% in a selected group of patients without clinical signs of prostate cancer) genetic variant in HOXB13 (G84E or rs138213197) have a 10-20-fold increased risk of prostate cancer.[4]

Contents

  • See also 1
  • References 2
  • Further reading 3
  • External links 4

See also

References

  1. ^ Zeltser L, Desplan C, Heintz N (Sep 1996). "Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity". Development 122 (8): 2475–84.  
  2. ^ Stelnicki EJ, Arbeit J, Cass DL, Saner C, Harrison M, Largman C (Jul 1998). "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds". J Invest Dermatol 111 (1): 57–63.  
  3. ^ a b "Entrez Gene: HOXB13 homeobox B13". 
  4. ^ Ewing C, et al (Jan 2012). "Germline mutations in HOXB13 and prostate cancer risk". New Engl J Med 366 (2): 141–9.  

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4.  
  • Shen WF, Montgomery JC, Rozenfeld S, et al. (1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins.". Mol. Cell. Biol. 17 (11): 6448–58.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56.  
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Kömüves LG, Ma XK, Stelnicki E, et al. (2004). "HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development.". Dev. Dyn. 227 (2): 192–202.  
  • Jung C, Kim RS, Lee SJ, et al. (2004). "HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4.". Cancer Res. 64 (9): 3046–51.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7.  
  • Jung C, Kim RS, Zhang HJ, et al. (2005). "HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling.". Cancer Res. 64 (24): 9185–92.  
  • Zhao Y, Yamashita T, Ishikawa M (2005). "Regulation of tumor invasion by HOXB13 gene overexpressed in human endometrial cancer.". Oncol. Rep. 13 (4): 721–6.  
  • Jung C, Kim RS, Zhang H, et al. (2005). "HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation.". Br. J. Cancer 92 (12): 2233–9.  
  • Symmans WF (2006). "Genomic testing for sensitivity of breast cancer to hormonal therapy.". Clin. Cancer Res. 12 (7 Pt 1): 1954–5.  
  • Goetz MP, Suman VJ, Ingle JN, et al. (2006). "A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen.". Clin. Cancer Res. 12 (7 Pt 1): 2080–7.  
  • Cazal C, Sobral AP, de Almeida FC, et al. (2006). "The homeobox HOXB13 is expressed in human minor salivary gland.". Oral diseases 12 (4): 424–7.  
  • Ma XJ, Hilsenbeck SG, Wang W, et al. (2006). "The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer.". J. Clin. Oncol. 24 (28): 4611–9.  
  • Muthusamy V, Duraisamy S, Bradbury CM, et al. (2007). "Epigenetic silencing of novel tumor suppressors in malignant melanoma.". Cancer Res. 66 (23): 11187–93.  
  • Miao J, Wang Z, Provencher H, et al. (2007). "HOXB13 promotes ovarian cancer progression.". Proc. Natl. Acad. Sci. U.S.A. 104 (43): 17093–8.  
  • Ewing C, et al. (2012). "Germline mutations in HOXB13 and prostate cancer risk.". New Engl J Med 366 (2): 141–9.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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