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Hoxb8

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Hoxb8

Homeobox B8
Identifiers
Symbols  ; HOX2; HOX2D; Hox-2.4
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.[1][2][3] This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of Homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog (see Homology (biology) § Orthology) of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.[3]

Transplantation of normal (wild-type) bone marrow into a Hoxb8 mutant mouse results is a reduction of compulsive grooming.[4]

See also

References

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460.  
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3.  
  3. ^ a b "Entrez Gene: HOXB8 homeobox B8". 
  4. ^ Shau-Kwaun Chen, Petr Tvrdik, Erik Peden, Scott Cho, Sen Wu1, Gerald Spangrude and  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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