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Title: Irf2  
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Subject: IRF6, IRF7, IRF8, Activation-induced cell death (AICD), Transcription factors
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Interferon regulatory factor 2

PDB rendering based on 1irf.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; IRF-2
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.[1] IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.[2]

See also


IRF2 has been shown to interact with BRD7,[3] EP300[4] and PCAF.[4][5]


  1. ^ Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T (September 1989). "Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes". Cell 58 (4): 729–39.  
  2. ^ "Entrez Gene: IRF2 interferon regulatory factor 2". 
  3. ^ Staal, A; Enserink J M; Stein J L; Stein G S; van Wijnen A J (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. (UNITED STATES) 185 (2): 269–79.  
  4. ^ a b Masumi, A; Ozato K (June 2001). "Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment". J. Biol. Chem. (United States) 276 (24): 20973–80.  
  5. ^ Masumi, A; Wang I M; Lefebvre B; Yang X J; Nakatani Y; Ozato K (March 1999). "The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness". Mol. Cell. Biol. (UNITED STATES) 19 (3): 1810–20.  

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