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Title: Irf7  
Author: World Heritage Encyclopedia
Language: English
Subject: IRF6, IRF5, IRF2, IRF4, STAT1
Collection: Transcription Factors
Publisher: World Heritage Encyclopedia


Interferon regulatory factor 7
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; IRF-7H; IRF7A; IRF7B; IRF7C; IRF7H
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors. IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes.[1] Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.[2]

The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response.[3] Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models.

The IRF7 gene and product were shown to be defective in a patient with severe susceptibility to H1N1 influenza, while susceptibility to other viral diseases such as CMV, RSV, and parainfluenza was unaffected.[4]


  • See also 1
  • Interactions 2
  • References 3
  • Further reading 4
  • External links 5

See also


IRF7 has been shown to interact with IRF3.[5]


  1. ^ Marié I; Durbin JE and Levy DE (November 1998). "Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7". EMBO J. 17 (22): 6660–9.  
  2. ^ "Entrez Gene: IRF7 interferon regulatory factor 7". 
  3. ^ Bidwell (2012). "Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape". Nature Medicine. Retrieved 23 July 2012. 
  4. ^ Jean-Laurent Casanova (2013). "Toward a Genetic Theory of Childhood Infectious Diseases". NIH. 
  5. ^ Au, W C; Yeow W S; Pitha P M (Feb 2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology (United States) 280 (2): 273–82.  

Further reading

  • Ning S*, Pagano J, Barber G. (2011. Epub ahead of print: 4/14/2011 PMID 21490621). "IRF7: activation, regulation, modification, and function. (Review).". Genes & Immunity. 
  • Pitha PM, Au WC, Lowther W et al. (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth". Biochimie 80 (8–9): 651–8.  
  • Zhang L, Pagano JS (2002). "Structure and function of IRF-7". J. Interferon Cytokine Res. 22 (1): 95–101.  
  • Zhang L, Pagano JS (1997). "IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency". Mol. Cell. Biol. 17 (10): 5748–57.  
  • Wathelet MG, Lin CH, Parekh BS et al. (1998). "Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo". Mol. Cell 1 (4): 507–18.  
  • Au WC, Moore PA, LaFleur DW et al. (1998). "Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes". J. Biol. Chem. 273 (44): 29210–7.  
  • Lu R, Au WC, Yeow WS et al. (2000). "Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon snd silencing by hypermethylation". J. Biol. Chem. 275 (41): 31805–12.  
  • Paris MJ, Williams BR (2001). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics 69 (2): 196–202.  
  • Marié I, Smith E, Prakash A, Levy DE (2000). "Phosphorylation-Induced Dimerization of Interferon Regulatory Factor 7 Unmasks DNA Binding and a Bipartite Transactivation Domain". Mol. Cell. Biol. 20 (23): 8803–14.  
  • Smith EJ, Marié I, Prakash A et al. (2001). "IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein". J. Biol. Chem. 276 (12): 8951–7.  
  • Au WC, Yeow WS, Pitha PM (2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology 280 (2): 273–82.  
  • Lu R, Moore PA, Pitha PM (2002). "Stimulation of IRF-7 gene expression by tumor necrosis factor alpha: requirement for NFkappa B transcription factor and gene accessibility". J. Biol. Chem. 277 (19): 16592–8.  
  • Morin P, Bragança J, Bandu MT et al. (2002). "Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription". J. Mol. Biol. 316 (5): 1009–22.  
  • Caillaud A, Prakash A, Smith E et al. (2003). "Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding". J. Biol. Chem. 277 (51): 49417–21.  
  • Izmailova E, Bertley FM, Huang Q et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7.  
  • Yang H, Lin CH, Ma G et al. (2003). "Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators". J. Biol. Chem. 278 (18): 15495–504.  
  • Ning S, Hahn AM, Huye LE, Pagano JS (2003). "Interferon Regulatory Factor 7 Regulates Expression of Epstein-Barr Virus Latent Membrane Protein 1: a Regulatory Circuit". J. Virol. 77 (17): 9359–68.  
  • Fitzgerald KA, Rowe DC, Barnes BJ et al. (2003). "LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF". J. Exp. Med. 198 (7): 1043–55.  
  • Lin R, Noyce RS, Collins SE et al. (2004). "The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-Mediated Activation of Interferon-Stimulated Genes". J. Virol. 78 (4): 1675–84.  

External links

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