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Title: Irx5  
Author: World Heritage Encyclopedia
Language: English
Subject: Iroquois homeobox factor, Homeobox, NeuroD, EMX homeogene, HOXC8
Publisher: World Heritage Encyclopedia


Iroquois homeobox 5
Symbols  ; HMMS; IRX-2a; IRXB2
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Iroquois-class homeodomain protein IRX-5, also known as Iroquois homeobox protein 5, is a protein that in humans is encoded by the IRX5 gene.[1][2]


  • Function 1
  • References 2
  • Further reading 3
  • External links 4


IRX5 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[1]


  1. ^ a b "Entrez Gene: iroquois homeobox 1". 
  2. ^ Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T (2001). "Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes". Cytogenet. Cell Genet. 92 (3-4): 320–5.  

Further reading

  • Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast.". Cell Tissue Res. 296 (3): 549–54.  
  • Bruneau BG (2006). "[Irx5: a transcription factor that regulates the cardiac repolarization gradient]". Med Sci (Paris) 22 (3): 231–2.  
  • Myrthue A, Rademacher BL, Pittsenbarger J, et al. (2008). "The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells.". Clin. Cancer Res. 14 (11): 3562–70.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Kanno S, Kuzuoka H, Sasao S, et al. (2007). "A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.". EMBO J. 26 (8): 2094–103.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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