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Title: Klf5  
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Subject: Induced pluripotent stem cell, NeuroD, EMX homeogene, Nur (biology), Early growth response proteins
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Kruppel-like factor 5 (intestinal)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; BTEB2; CKLF; IKLF
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.[1][2] This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.[2]


KLF5 has been shown to interact with Protein SET.[3]

See also


  1. ^ Sogawa K, Imataka H, Yamasaki Y, Kusume H, Abe H, Fujii-Kuriyama Y (May 1993). "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2". Nucleic Acids Res 21 (7): 1527–32.  
  2. ^ a b "Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)". 
  3. ^ Miyamoto, Saku; Suzuki Toru, Muto Shinsuke, Aizawa Kenichi, Kimura Akatsuki, Mizuno Yoshiko, Nagino Tomoko, Imai Yasushi, Adachi Naruhiko, Horikoshi Masami, Nagai Ryozo (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Mol. Cell. Biol. (United States) 23 (23): 8528–41.  

Further reading

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