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Lecithin—cholesterol acyltransferase

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Title: Lecithin—cholesterol acyltransferase  
Author: World Heritage Encyclopedia
Language: English
Subject: Cholesteryl ester, APOA5, LRP10, LRP3, LRP1B
Collection: Enzymes
Publisher: World Heritage Encyclopedia

Lecithin—cholesterol acyltransferase

Lecithin—cholesterol acyltransferase (LCAT, also called phosphatidylcholine-sterol O-acyltransferase) is an enzyme that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface. The enzyme is bound to high-density lipoproteins (HDLs) and low-density lipoproteins in the blood plasma.


  • Interactive pathway map 1
  • See also 2
  • References 3
  • Further reading 4
  • External links 5

Interactive pathway map

See also


Further reading

External links

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