World Library  
Flag as Inappropriate
Email this Article

MAF (gene)

Article Id: WHEBN0014771402
Reproduction Date:

Title: MAF (gene)  
Author: World Heritage Encyclopedia
Language: English
Subject: MAFF (gene), NFE2L2, Congenital cataract, NeuroD, EMX homeogene
Publisher: World Heritage Encyclopedia

MAF (gene)

V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
Symbols  ; CCA4; c-MAF
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Transcription factor Maf also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog is a transcription factor that in humans is encoded by the MAF gene.[1][2]


One type, MafA, also known as RIPE3b1,[3] promotes pancreatic development, as well as insulin gene transcription.[4]


MAF has been shown to interact with:


  1. ^ "Entrez Gene: MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)". 
  2. ^ Nishizawa M, Kataoka K, Goto N, Fujiwara KT, Kawai S (October 1989). "v-maf, a viral oncogene that encodes a "leucine zipper" motif". Proc. Natl. Acad. Sci. U.S.A. 86 (20): 7711–5.  
  3. ^ Olbrot M, Rud J, Moss LG, Sharma A (May 2002). "Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6737–42.  
  4. ^ Melloul D, Marshak S, Cerasi E (March 2002). "Regulation of insulin gene transcription". Diabetologia 45 (3): 309–26.  
  5. ^ a b Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (July 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. 277 (27): 24081–9.  
  6. ^ Hedge SP, Kumar A, Kurschner C, Shapiro LH (May 1998). "c-Maf Interacts with c-Myb To Regulate Transcription of an Early Myeloid Gene during Differentiation". Mol. Cell. Biol. 18 (5): 2729–37.  
  7. ^ Huang W, Lu N, Eberspaecher H, De Crombrugghe B (December 2002). "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". J. Biol. Chem. 277 (52): 50668–75.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.