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Title: Mesp2  
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Subject: NeuroD, EMX homeogene, NOBOX, Nur (biology), Winged-helix transcription factors
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Mesoderm posterior bHLH transcription factor 2
Symbols  ; SCDO2; bHLHc6
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Mesoderm posterior protein 2 (MESP2), also known as class C basic helix-loop-helix protein 6 (bHLHc6), is a protein that in humans is encoded by the MESP2 gene.[1]


This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm.[1] In zebrafish, the homolog mesp-b is critical for dermomyotome development.[2]

Clinical significance

Mutations in the MESP2 gene cause autosomal recessive Spondylocostal dysostosis type 2.[3]


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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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