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Title: Mycl1  
Author: World Heritage Encyclopedia
Language: English
Subject: MAX (gene), NeuroD, EMX homeogene, NOBOX, Nur (biology)
Publisher: World Heritage Encyclopedia


V-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
Symbols  ; LMYC; MYCL1; bHLHe38
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.[1][2]

MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.[3]


MYCL1 has been shown to interact with MAX.[4][5]


  1. ^ Speleman F, Van Camp G, Van Roy N (Jan 1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet 72 (2–3): 189–190.  
  2. ^ "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)". 
  3. ^ Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9.  
  4. ^ Blackwood, E M; Eisenman R N (Mar 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc".  
  5. ^ FitzGerald, M J; Arsura M; Bellas R E; Yang W; Wu M; Chin L; Mann K K; DePinho R A; Sonenshein G E (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene (ENGLAND) 18 (15): 2489–2498.  

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