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Title: Myf5  
Author: World Heritage Encyclopedia
Language: English
Subject: Myogenesis, PITX2, Myosatellite cell, Transcription factor, Human genes
Publisher: World Heritage Encyclopedia


Myogenic factor 5
Symbols  ; bHLHc2
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. [1] It is a protein with a key role in regulating muscle differentiation or myogenesis. Without Myf5 and MyoD, myogenic cells will fail to progress normally during the determination stage of myogenesis due to underscoring of the dynamics between cell populations and MRF regulation.

Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. MRF family members include Myf5, MyoD (Myf3), myogenin, and MRF4 (Myf6).[2]


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