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Ncoa4

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Ncoa4

Nuclear receptor coactivator 4
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; ARA70; ELE1; PTC3; RFG
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Nuclear receptor coactivator 4 is a protein that in humans is encoded by the NCOA4 gene.[1][2][3]


Interactions

NCOA4 has been shown to interact with:

See also

References

  1. ^ Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (February 1994). "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene 9 (2): 509–16. PMID 8290261. 
  2. ^ a b Yeh S, Chang C (July 1996). "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proc Natl Acad Sci U S A 93 (11): 5517–21. PMC 39278. PMID 8643607. doi:10.1073/pnas.93.11.5517. 
  3. ^ "Entrez Gene: NCOA4 Nuclear receptor coactivator 4". 
  4. ^ Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B (January 1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Mol. Endocrinol. 13 (1): 117–28. PMID 9892017. doi:10.1210/mend.13.1.0214. 
  5. ^ Miyamoto H, Yeh S, Wilding G, Chang C (June 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7379–84. PMC 22623. PMID 9636157. doi:10.1073/pnas.95.13.7379. 
  6. ^ Lin HK, Yeh S, Kang HY, Chang C (June 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7200–5. PMC 34646. PMID 11404460. doi:10.1073/pnas.121173298. 
  7. ^ Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C (May 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proc. Natl. Acad. Sci. U.S.A. 96 (10): 5458–63. PMC 21881. PMID 10318905. doi:10.1073/pnas.96.10.5458. 
  8. ^ Zhou ZX, He B, Hall SH, Wilson EM, French FS (February 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Mol. Endocrinol. 16 (2): 287–300. PMID 11818501. doi:10.1210/mend.16.2.0765. 
  9. ^ He B, Minges JT, Lee LW, Wilson EM (March 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". J. Biol. Chem. 277 (12): 10226–35. PMID 11779876. doi:10.1074/jbc.M111975200. 
  10. ^ Gao T, Brantley K, Bolu E, McPhaul MJ (October 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Mol. Endocrinol. 13 (10): 1645–56. PMID 10517667. doi:10.1210/mend.13.10.0352. 
  11. ^ He B, Wilson EM (March 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. PMC 149467. PMID 12612084. doi:10.1128/mcb.23.6.2135-2150.2003. 
  12. ^ Heinlein CA, Ting HJ, Yeh S, Chang C (June 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". J. Biol. Chem. 274 (23): 16147–52. PMID 10347167. doi:10.1074/jbc.274.23.16147. 

External links

Further reading

  • Minoletti F, Butti MG, Coronelli S, et al. (1995). "The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2.". Genes Chromosomes Cancer 11 (1): 51–7. PMID 7529046. doi:10.1002/gcc.2870110108. 
  • Jhiang SM, Smanik PA, Mazzaferri EL (1994). "Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma.". Cancer Lett. 78 (1-3): 69–76. PMID 8180971. doi:10.1016/0304-3835(94)90033-7. 
  • Bongarzone I, Butti MG, Coronelli S, et al. (1994). "Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas.". Cancer Res. 54 (11): 2979–85. PMID 8187085. 
  • Bongarzone I, Butti MG, Fugazzola L, et al. (1997). "Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas.". Genomics 42 (2): 252–9. PMID 9192845. doi:10.1006/geno.1997.4685. 
  • Miyamoto H, Yeh S, Wilding G, Chang C (1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells.". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7379–84. PMC 22623. PMID 9636157. doi:10.1073/pnas.95.13.7379. 
  • Alen P, Claessens F, Schoenmakers E, et al. (1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform.". Mol. Endocrinol. 13 (1): 117–28. PMID 9892017. doi:10.1210/mend.13.1.0214. 
  • Kang HY, Yeh S, Fujimoto N, Chang C (1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor.". J. Biol. Chem. 274 (13): 8570–6. PMID 10085091. doi:10.1074/jbc.274.13.8570. 
  • Yeh S, Lin HK, Kang HY, et al. (1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (10): 5458–63. PMC 21881. PMID 10318905. doi:10.1073/pnas.96.10.5458. 
  • Heinlein CA, Ting HJ, Yeh S, Chang C (1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma.". J. Biol. Chem. 274 (23): 16147–52. PMID 10347167. doi:10.1074/jbc.274.23.16147. 
  • Gao T, Brantley K, Bolu E, McPhaul MJ (1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays.". Mol. Endocrinol. 13 (10): 1645–56. PMID 10517667. doi:10.1210/mend.13.10.0352. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMC 310948. PMID 11076863. doi:10.1101/gr.143000. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. PMC 311072. PMID 11230166. doi:10.1101/gr.GR1547R. 
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. PMC 1083732. PMID 11256614. doi:10.1093/embo-reports/kvd058. 
  • Lin HK, Yeh S, Kang HY, Chang C (2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7200–5. PMC 34646. PMID 11404460. doi:10.1073/pnas.121173298. 
  • Basolo F, Giannini R, Monaco C, et al. (2002). "Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma.". Am. J. Pathol. 160 (1): 247–54. PMC 1867131. PMID 11786418. doi:10.1016/S0002-9440(10)64368-4. 
  • Zhou ZX, He B, Hall SH, et al. (2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR).". Mol. Endocrinol. 16 (2): 287–300. PMID 11818501. doi:10.1210/mend.16.2.0765. 
  • Thin TH, Kim E, Yeh S, et al. (2002). "Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation.". J. Biol. Chem. 277 (39): 36499–508. PMID 12068007. doi:10.1074/jbc.M202824200. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 

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