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Title: Ncoa6  
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Subject: Androgen receptor, EP300, Transcription coregulator, Estrogen receptor alpha, CREB-binding protein
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Nuclear receptor coactivator 6
NCOA6 Gene
RNA expression pattern

Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.[1][2][3]

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.[3]


NCOA6 has been shown to interact with Ku70,[4][5] RBBP5,[6] E2F1,[7] Retinoblastoma protein,[8] CREB-binding protein,[9][10] Activating transcription factor 2,[11] HSF1,[12] HBXIP,[13] TGS1,[14][15] TUBB,[6] TUBA4A,[6] Thyroid hormone receptor beta,[4][9][10][16] Retinoic acid receptor alpha,[4][9][10] Src,[6][9][10][17] Thyroid hormone receptor alpha,[9][17] DNA-PKcs,[4] Androgen receptor,[8] HIST2H3C,[6] MLL3,[6] Ku80,[4][5] Liver X receptor beta,[10] Estrogen receptor alpha,[9][16] Estrogen receptor beta,[10][16] EP300,[4] ASCL2[6] and Retinoid X receptor alpha.[9][10][13][16]

See also


External links

  • Medical Subject Headings (MeSH)
  • C94

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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