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Title: Nfia  
Author: World Heritage Encyclopedia
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Subject: Nuclear factor I, Transcription factor, NeuroD, EMX homeogene, Engrailed (gene)
Collection: Transcription Factors
Publisher: World Heritage Encyclopedia


Nuclear factor I/A
Symbols  ; CTF; NF-I/A; NF1-A; NFI-A; NFI-L
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Nuclear factor 1 A-type is a protein that in humans is encoded by the NFIA gene.[1][2] Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. They function as cellular transcription factors and as replication factors for adenovirus DNA replication. Diversity in this protein family is generated by multiple genes, differential splicing, and heterodimerization.[supplied by OMIM][2]


  1. ^ Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics 28 (1): 66–73.  
  2. ^ a b "Entrez Gene: NFIA nuclear factor I/A". 

Further reading

  • Leahy P, Crawford DR, Grossman G, et al. (1999). "CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription.". J. Biol. Chem. 274 (13): 8813–22.  
  • das Neves L, Duchala CS, Tolentino-Silva F, et al. (1999). "Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum.". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11946–51.  
  • Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5.  
  • Xu H, Uno JK, Inouye M, et al. (2005). "NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene.". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G175–81.  
  • Wang W, Stock RE, Gronostajski RM, et al. (2005). "A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression.". J. Biol. Chem. 279 (51): 53491–7.  
  • Champ PC, Maurice S, Vargason JM, et al. (2005). "Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation.". Nucleic Acids Res. 32 (22): 6501–10.  
  • Berry FB, O'Neill MA, Coca-Prados M, Walter MA (2005). "FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner.". Mol. Cell. Biol. 25 (4): 1415–24.  
  • Fazi F, Rosa A, Fatica A, et al. (2006). "A minicircuitry composed of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis.". Cell 123 (5): 819–31.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21.  
  • Lin YL, Wang YH, Lee HJ (2006). "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A.". Biochem. Biophys. Res. Commun. 350 (2): 430–6.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48.  
  • Lu W, Quintero-Rivera F, Fan Y, et al. (2007). "NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects.". PLoS Genet. 3 (5): e80.  

External links

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