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Nkx3-2

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Title: Nkx3-2  
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Subject: NKX-homeodomain factor, Homeobox, Transcription factors, NeuroD, EMX homeogene
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Nkx3-2

NK3 homeobox 2
Identifiers
Symbols  ; BAPX1; NKX3.2; NKX3B; SMMD
External IDs GeneCards:
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of bagpipe(bap) in Drosophila and therefore also known as Bapx1 (bagpipe homeobox homolog 1) . The protein encoded by this gene is a homeo domain containing transcription factor.[1]

Function

NKX3-2 plays a role in the development of the skeleton.[2] Nkx3-2 in mice also regulates patterning in the middle ear.[3]

References

  1. ^ Yoshiura KI, Murray JC (October 1997). "Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia". Genomics 45 (2): 425–8.  
  2. ^ Lettice L, Hecksher-Sørensen J, Hill R (2001). "The role of Bapx1 (Nkx3.2) in the development and evolution of the axial skeleton". J. Anat. 199 (Pt 1–2): 181–7.  
  3. ^ Tucker AS, Watson RP, Lettice LA, Yamada G, Hill RE (2004). "Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution". Development 131 (6): 1235–1245.  

External links

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