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Pax4

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Pax4

Paired box 4
Identifiers
Symbols  ; KPD; MODY9
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Paired box gene 4, also known as PAX4, is a protein which in humans is encoded by the PAX4 gene.[1][2][3]

Function

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box gene 4 is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.[1]

See also

References

  1. ^ a b "Entrez Gene: PAX4 paired box gene 4". 
  2. ^ Matsushita T, Yamaoka T, Otsuka S, Moritani M, Matsumoto T, Itakura M (January 1998). "Molecular cloning of mouse paired-box-containing gene (Pax)-4 from an islet beta cell line and deduced sequence of human Pax-4". Biochem. Biophys. Res. Commun. 242 (1): 176–80.  
  3. ^ Inoue H, Nomiyama J, Nakai K, Matsutani A, Tanizawa Y, Oka Y (February 1998). "Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue". Biochem. Biophys. Res. Commun. 243 (2): 628–33.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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