World Library  
Flag as Inappropriate
Email this Article

Philippa Marrack

Article Id: WHEBN0014400600
Reproduction Date:

Title: Philippa Marrack  
Author: World Heritage Encyclopedia
Language: English
Subject: John Kappler, William B. Coley Award, Paul Ehrlich and Ludwig Darmstaedter Prize, Colorado Women's Hall of Fame, Anna Lee Aldred
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Philippa Marrack

Philippa "Pippa" Marrack
Born (1945-06-18) 18 June 1945
Ewell, England
Institutions National Jewish Health
Alma mater Cambridge University
University of California, San Diego
Doctoral advisor Alan Munro
Known for T cells, autoimmune disease
Notable awards Louisa Gross Horwitz Prize (1995)
Dickson Prize (1996)
Spouse John W. Kappler

Philippa "Pippa" Marrack FRS (born 18 June 1945) is an English biologist, based in the United States, best known for her research into T cell development, T cell apoptosis and survival, adjuvants, autoimmune disease, and for identifying superantigens, the mechanism behind toxic shock syndrome.[1] She collaborates with her husband, John W. Kappler.

Biography

Marrack was born in Ewell, England on 18 June 1945.[2] She completed both undergraduate and Ph.D. work at New Hall, Cambridge. To earn her Ph.D, she worked at the MRC Laboratory of Molecular Biology with Alan Munro, where she began to work on T cells. She later did postdoctoral work with Richard Dutton at the University of California, San Diego.

Her first faculty position was with the University of Rochester, followed by National Jewish Health, Denver, Colorado and the University of Colorado.

Significant papers

  • J.W. Kappler, M. Roehm, P. Marrack, "T cell tolerance by clonal elimination in the thymus," Cell, v.49, n.2, pp. 273–80 (1987)
  • P. Marrack and J. Kappler, "The Staphylococcal Enterotoxins and Their Relatives," Science, v.248 (4956), pp. 705–11 (1990).
  • J.W. Kappler, U. Staerz, J. White, P.C. Marrack, "Self-Tolerance Eliminates T Cells Specific for MIS-Modified Products of the Major Histocompatibility Complex," Nature, 332 (6159): pp. 35–40 (1988).
  • J. White, et al. (P.C. Marrack), "The V(beta)-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletions in neonatal mice," Cell, v.56, n.1, pp. 27–35 (1989).

Awards

References

  1. ^ Rennie, J. (1992) Profile: Philippa Marrack and John Kappler – Keeping It In the Family, Scientific American 267(2), 43-44.
  2. ^ Yount, Lisa (2007). "Marrack, Philippa". A to Z of Women in Science and Math (Rev. ed.). New York: Infobase Pub. p. 191.  
  3. ^ "Philippa Marack To Be Honored for Lifetime Achievement in Immunology", May 4, 2003.
  4. ^ AAI Award History
  5. ^ Immunologist "Philippa Marrack to Receive Rockefeller University's Pearl Meister Greengard Prize", Nov. 2, 2005.

Further reading

  • HHMI Profile of work
  • "Becoming a Scientist", Philippa Marrack, HHMI
  • "Philippa Marrack Targets T Cells and Autoimmune Disease", ScienceWatch
  • Christine Bahls, "Philippa Marrack", 'The Scientist v.18, n.6, p. 13 (2004).
  • "Profile: Philippa Marrack", Nature Medicine, v.10, n.12.

External links

  • Kappler/Marrack Lab
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.