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Rnf14

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Rnf14

Ring finger protein 14
Identifiers
RNF14 Gene
RNA expression pattern

E3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.[1][2][3]

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.[3]

See also

Interactions

RNF14 has been shown to interact with Androgen receptor.[1][4][5][6]

References

External links

  • Medical Subject Headings (MeSH)
  • C127

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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