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Retinoblastoma-like protein 1

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Title: Retinoblastoma-like protein 1  
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Subject: MYBL2, Cyclin A2, Transcription factors, NeuroD, EMX homeogene
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Retinoblastoma-like protein 1

Retinoblastoma-like 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; CP107; PRB1; p107
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene.[1][2]


  • Function 1
  • Interactions 2
  • See also 3
  • References 4
  • Further reading 5
  • External links 6


The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 Large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.[1]


Retinoblastoma-like protein 1 has been shown to interact with HDAC1,[3][4] RBBP8,[5][6] E2F1,[7] Cyclin-dependent kinase 2,[8][9] BEGAIN,[6] BRF1,[10] BRCA1,[11] Cyclin A2,[7][12] Prohibitin,[13] MYBL2[12][14] and Mothers against decapentaplegic homolog 3.[15]

See also


  1. ^ a b "Entrez Gene: RBL1 retinoblastoma-like 1 (p107)". 
  2. ^ Ewen ME, Xing YG, Lawrence JB, Livingston DM (September 1991). "Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein". Cell 66 (6): 1155–64.  
  3. ^ Lai, A; Lee J M; Yang W M; DeCaprio J A; Kaelin W G; Seto E; Branton P E (October 1999). "RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins". Mol. Cell. Biol. (UNITED STATES) 19 (10): 6632–41.  
  4. ^ Ferreira, R; Magnaghi-Jaulin L; Robin P; Harel-Bellan A; Trouche D (September 1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase".  
  5. ^ Fusco, C; Reymond A; Zervos A S (August 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics (UNITED STATES) 51 (3): 351–8.  
  6. ^ a b Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".  
  7. ^ a b Dyson, N; Dembski M; Fattaey A; Ngwu C; Ewen M; Helin K (Dec 1993). "Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1". J. Virol. (UNITED STATES) 67 (12): 7641–7.  
  8. ^ Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. (UNITED STATES) 19 (2): 1460–9.  
  9. ^ Leng, Xiaohong; Noble Martin; Adams Peter D; Qin Jun; Harper J Wade (April 2002). "Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4". Mol. Cell. Biol. (United States) 22 (7): 2242–54.  
  10. ^ Sutcliffe, J E; Cairns C A; McLees A; Allison S J; Tosh K; White R J (June 1999). "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130". Mol. Cell. Biol. (UNITED STATES) 19 (6): 4255–61.  
  11. ^ Fan, S; Yuan R; Ma Y X; Xiong J; Meng Q; Erdos M; Zhao J N; Goldberg I D; Pestell R G; Rosen E M (August 2001). "Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding". Oncogene (England) 20 (35): 4827–41.  
  12. ^ a b Joaquin, Manel; Bessa Maria; Saville Mark K; Watson Roger J (November 2002). "B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107". Oncogene (England) 21 (52): 7923–32.  
  13. ^ Wang, S; Nath N; Adlam M; Chellappan S (June 1999). "Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function". Oncogene (ENGLAND) 18 (23): 3501–10.  
  14. ^ Joaquin, Manel; Watson Roger J (November 2003). "The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclin-binding domain". J. Biol. Chem. (United States) 278 (45): 44255–64.  
  15. ^ Chen, Chang-Rung; Kang Yibin; Siegel Peter M; Massagué Joan (July 2002). "E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression". Cell (United States) 110 (1): 19–32.  

Further reading

  • Faha B, Ewen ME, Tsai LH, et al. (1992). "Interaction between human cyclin A and adenovirus E1A-associated p107 protein.". Science 255 (5040): 87–90.  
  • Ewen ME, Xing YG, Lawrence JB, Livingston DM (1991). "Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein.". Cell 66 (6): 1155–64.  
  • Datta PK, Raychaudhuri P, Bagchi S (1995). "Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription.". Mol. Cell. Biol. 15 (10): 5444–52.  
  • Zhu L, Zhu L, Xie E, Chang LS (1995). "Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins.". Mol. Cell. Biol. 15 (7): 3552–62.  
  • Sardet C, Vidal M, Cobrinik D, et al. (1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403–7.  
  • Kim YW, Otterson GA, Kratzke RA, et al. (1994). "Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.". Mol. Cell. Biol. 14 (11): 7256–64.  
  • Ginsberg D, Vairo G, Chittenden T, et al. (1994). "E2F-4, a new member of the E2F transcription factor family, interacts with p107.". Genes Dev. 8 (22): 2665–79.  
  • Beijersbergen RL, Kerkhoven RM, Zhu L, et al. (1994). "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.". Genes Dev. 8 (22): 2680–90.  
  • Beijersbergen RL, Hijmans EM, Zhu L, Bernards R (1994). "Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation.". EMBO J. 13 (17): 4080–6.  
  • Dyson N, Dembski M, Fattaey A, et al. (1993). "Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1.". J. Virol. 67 (12): 7641–7.  
  • Zhu L, van den Heuvel S, Helin K, et al. (1993). "Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.". Genes Dev. 7 (7A): 1111–25.  
  • Ikeda MA, Jakoi L, Nevins JR (1996). "A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.". Proc. Natl. Acad. Sci. U.S.A. 93 (8): 3215–20.  
  • Xiao ZX, Ginsberg D, Ewen M, Livingston DM (1996). "Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4633–7.  
  • Vidal M, Brachmann RK, Fattaey A, et al. (1996). "Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10315–20.  
  • Shao Z, Siegert JL, Ruppert S, Robbins PD (1997). "Rb interacts with TAF(II)250/TFIID through multiple domains.". Oncogene 15 (4): 385–92.  
  • Verona R, Moberg K, Estes S, et al. (1997). "E2F activity is regulated by cell cycle-dependent changes in subcellular localization.". Mol. Cell. Biol. 17 (12): 7268–82.  
  • Trimarchi JM, Fairchild B, Verona R, et al. (1998). "E2F-6, a member of the E2F family that can behave as a transcriptional repressor.". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2850–5.  
  • Sterner JM, Dew-Knight S, Musahl C, et al. (1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.". Mol. Cell. Biol. 18 (5): 2748–57.  
  • Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability.". Nat. Genet. 19 (4): 371–4.  
  • Veal E, Eisenstein M, Tseng ZH, Gill G (1998). "A cellular repressor of E1A-stimulated genes that inhibits activation by E2F.". Mol. Cell. Biol. 18 (9): 5032–41.  

External links

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