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Retinoblastoma-like protein 2

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Title: Retinoblastoma-like protein 2  
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Subject: Cyclin E1, Transcription factors, NeuroD, EMX homeogene, NOBOX
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Retinoblastoma-like protein 2

Retinoblastoma-like 2
Symbols  ; P130; Rb2
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.[1][2]


Retinoblastoma-like protein 2 has been shown to interact with HDAC1,[3][4] C-Raf,[5] RBBP8,[6][7] Cyclin E1,[8][9] Prohibitin,[10] Cyclin-dependent kinase 2,[8][11] BRF1[12] and BRCA1.[13]

See also

Further reading


  1. ^ Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A (September 1993). "Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain". Oncogene 8 (9): 2561–6.  
  2. ^ Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (July 1996). "Genomic structure of the human retinoblastoma-related Rb2/p130 gene". Proc Natl Acad Sci U S A 93 (10): 4629–32.  
  3. ^ Ferreira, R; Magnaghi-Jaulin L; Robin P; Harel-Bellan A; Trouche D (September 1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase".  
  4. ^ Bouzahzah, B; Fu M; Iavarone A; Factor V M; Thorgeirsson S S; Pestell R G (August 2000). "Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo". Cancer Res. (UNITED STATES) 60 (16): 4531–7.  
  5. ^ Wang, S; Ghosh R N; Chellappan S P (Dec 1998). "Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation". Mol. Cell. Biol. (UNITED STATES) 18 (12): 7487–98.  
  6. ^ Meloni, A R; Smith E J; Nevins J R (August 1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor".  
  7. ^ Fusco, C; Reymond A; Zervos A S (August 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics (UNITED STATES) 51 (3): 351–8.  
  8. ^ a b Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. (UNITED STATES) 19 (2): 1460–9.  
  9. ^ Li, Y; Graham C; Lacy S; Duncan A M; Whyte P (Dec 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes Dev. (UNITED STATES) 7 (12A): 2366–77.  
  10. ^ Wang, S; Nath N; Adlam M; Chellappan S (June 1999). "Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function". Oncogene (ENGLAND) 18 (23): 3501–10.  
  11. ^ Lacy, S; Whyte P (May 1997). "Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes". Oncogene (ENGLAND) 14 (20): 2395–406.  
  12. ^ Sutcliffe, J E; Cairns C A; McLees A; Allison S J; Tosh K; White R J (June 1999). "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130". Mol. Cell. Biol. (UNITED STATES) 19 (6): 4255–61.  
  13. ^ Fan, S; Yuan R; Ma Y X; Xiong J; Meng Q; Erdos M; Zhao J N; Goldberg I D; Pestell R G; Rosen E M (August 2001). "Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding". Oncogene (England) 20 (35): 4827–41.  

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