World Library  
Flag as Inappropriate
Email this Article

Roderick MacKinnon

Article Id: WHEBN0000870771
Reproduction Date:

Title: Roderick MacKinnon  
Author: World Heritage Encyclopedia
Language: English
Subject: Ion channel, Nobel Prize in Chemistry, List of Nobel laureates by university affiliation, Gheorghe Benga, Julian Voss-Andreae
Collection: 1956 Births, American Biophysicists, American Neuroscientists, American Nobel Laureates, American People of Scottish Descent, Brandeis University Alumni, Brookhaven National Laboratory Nobel Laureates, Harvard University Faculty, Howard Hughes Medical Investigators, Living People, Members of the United States National Academy of Sciences, Nobel Laureates in Chemistry, People from Burlington, Massachusetts, Recipients of the Albert Lasker Award for Basic Medical Research, Tufts University Alumni, Tufts University School of Medicine Alumni
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Roderick MacKinnon

Roderick MacKinnon
Born (1956-02-19) 19 February 1956
Burlington, Massachusetts, USA
Nationality United States
Fields Chemistry
Alma mater Brandeis University
Notable awards Newcomb Cleveland Prize (1997)
Albert Lasker Award for Basic Medical Research (1999)
Perl-UNC Prize (2001)
Nobel Prize in Chemistry (2003)
Louisa Gross Horwitz Prize (2003)

Roderick MacKinnon (born 19 February 1956) is a professor of Molecular Neurobiology and Biophysics at Rockefeller University who won the Nobel Prize in Chemistry together with Peter Agre in 2003 for his work on the structure and operation of ion channels.[1][2][3]

Contents

  • Biography 1
    • Early life and education 1.1
    • Career 1.2
  • Scientific contributions 2
  • References 3
  • External links 4

Biography

Early life and education

MacKinnon was born in Burlington, Massachusetts and initially attended the University of Massachusetts Boston. MacKinnon then transferred to Brandeis University after one year, and there he received a bachelor's degree in biochemistry in 1978, studying calcium transport through the cell membrane for his honors thesis in Christopher Miller's laboratory. It was also at Brandeis where MacKinnon met his future wife and working-colleague Alice Lee.[4]

After receiving his degree from Brandeis, MacKinnon entered medical school at Tufts University.[3] He got his M.D. in 1982 and received training in Internal Medicine at Beth Israel Hospital in Boston. He did not feel satisfied enough with the medical profession, so in 1986 he returned to Christopher Miller's laboratory at Brandeis for postdoctoral studies.[4]

Career

In 1989 he was appointed assistant professor at Harvard University where he studied the interaction of the potassium channel with a specific toxin derived from scorpion venom, acquainting himself with methods of protein purification and X-ray crystallography. In 1996 he moved to Rockefeller University as a professor and head of the Laboratory of Molecular Neurobiology and Biophysics where he started to work on the structure of the potassium channel. These channels are of particular importance to the nervous system and the heart and enable potassium ions to cross the cell membrane.

Scientific contributions

Potassium channels demonstrate a seemingly counterintuitive activity: they permit the passage of potassium ions, whereas they do not allow the passage of the much smaller sodium ions. Before MacKinnon's work, the detailed molecular architecture of potassium channels and the exact means by which they conduct ions remained speculative. In 1998, despite barriers to the structural study of integral membrane proteins that had thwarted most attempts for decades, MacKinnon and colleagues determined the three-dimensional molecular structure of a potassium channel from an actinobacteria, Streptomyces lividans, utilizing X-ray crystallography. With this structure and other biochemical experiments, MacKinnon and colleagues were able to explain the exact mechanism by which potassium channel selectivity occurs.[5][6]

His prize-winning research was conducted primarily at the Cornell High Energy Synchrotron Source (CHESS) of Cornell University, and at the National Synchrotron Light Source (NSLS) of Brookhaven National Laboratory.[7]

References

  1. ^ "2003 Nobel Prize in Chemistry Awarded to Researcher Roderick MacKinnon". Brookhaven National Labs. October 8, 2003. Retrieved 11 February 2010. 
  2. ^ "Nobel Prize honors Rockefeller University scientist Roderick MacKinnon for revealing process of electrical signaling in humans and other living organisms". The Rockefeller University. October 8, 2003. Retrieved 11 February 2010. 
  3. ^ a b Birmingham K (June 2001). "Rod MacKinnon". Nat. Med. 7 (6): 648.  
  4. ^ a b MacKinnon, Roderick (October 2003). Editor Tore Frängsmyr, ed. The Nobel Prizes 2003. Stockholm, Sweden: Nobel Foundation. Retrieved 11 February 2010. 
  5. ^ MacKinnon R, Cohen SL, Kuo A, Lee A, Chait BT (April 1998). "Structural conservation in prokaryotic and eukaryotic potassium channels". Science 280 (5360): 106–9.  
  6. ^ Doyle DA, Morais Cabral J, Pfuetzner RA, et al. (April 1998). "The structure of the potassium channel: molecular basis of K+ conduction and selectivity". Science 280 (5360): 69–77.  
  7. ^ "The Chemistry of the Cell". Brookhaven National Lab. Retrieved 13 March 2010. 

External links

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 



Copyright © World Library Foundation. All rights reserved. eBooks from Hawaii eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.